Cortical Firing and Sleep Homeostasis

Vladyslav V. Vyazovskiy, Umberto Olcese, Yaniv M. Lazimy, Ugo Faraguna, Steve K. Esser, Justin C. Williams, Chiara Cirelli, Giulio Tononi

Research output: Contribution to journalArticle

Abstract

The need to sleep grows with the duration of wakefulness and dissipates with time spent asleep, a process called sleep homeostasis. What are the consequences of staying awake on brain cells, and why is sleep needed? Surprisingly, we do not know whether the firing of cortical neurons is affected by how long an animal has been awake or asleep. Here, we found that after sustained wakefulness cortical neurons fire at higher frequencies in all behavioral states. During early NREM sleep after sustained wakefulness, periods of population activity (ON) are short, frequent, and associated with synchronous firing, while periods of neuronal silence are long and frequent. After sustained sleep, firing rates and synchrony decrease, while the duration of ON periods increases. Changes in firing patterns in NREM sleep correlate with changes in slow-wave activity, a marker of sleep homeostasis. Thus, the systematic increase of firing during wakefulness is counterbalanced by staying asleep.

Original languageEnglish
Pages (from-to)865-878
Number of pages14
JournalNeuron
Volume63
Issue number6
DOIs
Publication statusPublished - Sep 24 2009

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Keywords

  • SIGNALING
  • SYSBIO
  • SYSNEURO

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Vyazovskiy, V. V., Olcese, U., Lazimy, Y. M., Faraguna, U., Esser, S. K., Williams, J. C., Cirelli, C., & Tononi, G. (2009). Cortical Firing and Sleep Homeostasis. Neuron, 63(6), 865-878. https://doi.org/10.1016/j.neuron.2009.08.024