Cortical functional correlates of responsiveness to short-lasting preventive intervention with ketogenic diet in migraine

a multimodal evoked potentials study

Cherubino Di Lorenzo, Gianluca Coppola, Martina Bracaglia, Davide Di Lenola, Maurizio Evangelista, Giulio Sirianni, Paolo Rossi, Giorgio Di Lorenzo, Mariano Serrao, Vincenzo Parisi, Francesco Pierelli

Research output: Contribution to journalArticle

Abstract

Background: Here, we aim to identify cortical electrofunctional correlates of responsiveness to short-lasting preventiveintervention with ketogenic diet (KD) in migraine. Methods: Eighteen interictal migraineurs underwent visual (VEPs) and median nerve somatosensory (SSEPs) evokedpotentials before and after 1 month of KD during ketogenesis. We measured VEPs N1-P1 and SSEPs N20-P25 amplitudes respectively in six and in two sequential blocks of 100 sweeps as well as habituation as theslope of the linear regression between block 1 to 6 for VEPs or between 1 to 2 for SSEPs. Results: After 1-month of KD, a significant reduction in the mean attack frequency and duration was observed (all P<0.001). The KD did not change the 1st SSEP and VEP block of responses, but significantly inducednormalization of the interictally reduced VEPs and SSEPs (all p <0.01) habituation during the subsequentblocks. Conclusions: KD could restore normal EPs habituation curves during stimulus repetition without significantly changing theearly amplitude responses. Thus, we hypothesize that KD acts on habituation regulating the balancebetween excitation and inhibition at the cortical level.

Original languageEnglish
Article number58
JournalJournal of Headache and Pain
Volume17
Issue number1
DOIs
Publication statusPublished - Dec 1 2016

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Ketogenic Diet
Migraine Disorders
Evoked Potentials
Median Nerve
Linear Models

Keywords

  • Diet
  • Habituation
  • Ketogenesis
  • Migraine
  • Somatosensory-evoked potentials
  • Visual-evoked potentials

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Clinical Neurology

Cite this

Cortical functional correlates of responsiveness to short-lasting preventive intervention with ketogenic diet in migraine : a multimodal evoked potentials study. / Di Lorenzo, Cherubino; Coppola, Gianluca; Bracaglia, Martina; Di Lenola, Davide; Evangelista, Maurizio; Sirianni, Giulio; Rossi, Paolo; Di Lorenzo, Giorgio; Serrao, Mariano; Parisi, Vincenzo; Pierelli, Francesco.

In: Journal of Headache and Pain, Vol. 17, No. 1, 58, 01.12.2016.

Research output: Contribution to journalArticle

Di Lorenzo, Cherubino ; Coppola, Gianluca ; Bracaglia, Martina ; Di Lenola, Davide ; Evangelista, Maurizio ; Sirianni, Giulio ; Rossi, Paolo ; Di Lorenzo, Giorgio ; Serrao, Mariano ; Parisi, Vincenzo ; Pierelli, Francesco. / Cortical functional correlates of responsiveness to short-lasting preventive intervention with ketogenic diet in migraine : a multimodal evoked potentials study. In: Journal of Headache and Pain. 2016 ; Vol. 17, No. 1.
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AU - Di Lenola, Davide

AU - Evangelista, Maurizio

AU - Sirianni, Giulio

AU - Rossi, Paolo

AU - Di Lorenzo, Giorgio

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AU - Parisi, Vincenzo

AU - Pierelli, Francesco

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