Cortical motor activation in akinetic schizoophrenic patients: A pilot functional MRI study

Pierre Payoux, Kader Boulanouar, Christine Sarramon, Nelly Fabre, Sylvie Descombes, Monique Galitsky, Claire Thalamas, Christine Brefel-Courbon, Umberto Sabatini, Claude Manelfe, François Chollet, Laurent Schmitt, Oliver Rascol

Research output: Contribution to journalArticlepeer-review


Akinesia is associated with supplementary motor area (SMA) dysfuncfion in Parkinson's disease. We looked for a similar association in patients with schizophrenia. Using functional magnetic resonance imaging (fMRI), we compared motor activation in 6 akinetic neuroleptic-treated schizophrenic patients and 6 normal subjects. Schizophrenic patients had a defective activation in the SMA, left primary sensorimotor cortex, bilateral lateral premotor and inferior panetal cortices, whereas the right primary sensorimotor cortex and a mesial frontal area were hyperactive. SMA was hypoactive in akinetic schizophrenic patients, emphasizing the role of this area in motor slowness. Other abnormal signals likely reflect schizophrenia-related abnormal intracortical connections.

Original languageEnglish
Pages (from-to)83-90
Number of pages8
JournalMovement Disorders
Issue number1
Publication statusPublished - Jan 2004


  • Akinesia
  • fMRI
  • Neuroleptics
  • Schizophrenia

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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