Cortical motor activation in akinetic schizoophrenic patients

A pilot functional MRI study

Pierre Payoux, Kader Boulanouar, Christine Sarramon, Nelly Fabre, Sylvie Descombes, Monique Galitsky, Claire Thalamas, Christine Brefel-Courbon, Umberto Sabatini, Claude Manelfe, François Chollet, Laurent Schmitt, Oliver Rascol

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Akinesia is associated with supplementary motor area (SMA) dysfuncfion in Parkinson's disease. We looked for a similar association in patients with schizophrenia. Using functional magnetic resonance imaging (fMRI), we compared motor activation in 6 akinetic neuroleptic-treated schizophrenic patients and 6 normal subjects. Schizophrenic patients had a defective activation in the SMA, left primary sensorimotor cortex, bilateral lateral premotor and inferior panetal cortices, whereas the right primary sensorimotor cortex and a mesial frontal area were hyperactive. SMA was hypoactive in akinetic schizophrenic patients, emphasizing the role of this area in motor slowness. Other abnormal signals likely reflect schizophrenia-related abnormal intracortical connections.

Original languageEnglish
Pages (from-to)83-90
Number of pages8
JournalMovement Disorders
Volume19
Issue number1
DOIs
Publication statusPublished - Jan 2004

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Motor Cortex
Magnetic Resonance Imaging
Schizophrenia
Antipsychotic Agents
Parkinson Disease
Sensorimotor Cortex

Keywords

  • Akinesia
  • fMRI
  • Neuroleptics
  • Schizophrenia

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Payoux, P., Boulanouar, K., Sarramon, C., Fabre, N., Descombes, S., Galitsky, M., ... Rascol, O. (2004). Cortical motor activation in akinetic schizoophrenic patients: A pilot functional MRI study. Movement Disorders, 19(1), 83-90. https://doi.org/10.1002/mds.10598

Cortical motor activation in akinetic schizoophrenic patients : A pilot functional MRI study. / Payoux, Pierre; Boulanouar, Kader; Sarramon, Christine; Fabre, Nelly; Descombes, Sylvie; Galitsky, Monique; Thalamas, Claire; Brefel-Courbon, Christine; Sabatini, Umberto; Manelfe, Claude; Chollet, François; Schmitt, Laurent; Rascol, Oliver.

In: Movement Disorders, Vol. 19, No. 1, 01.2004, p. 83-90.

Research output: Contribution to journalArticle

Payoux, P, Boulanouar, K, Sarramon, C, Fabre, N, Descombes, S, Galitsky, M, Thalamas, C, Brefel-Courbon, C, Sabatini, U, Manelfe, C, Chollet, F, Schmitt, L & Rascol, O 2004, 'Cortical motor activation in akinetic schizoophrenic patients: A pilot functional MRI study', Movement Disorders, vol. 19, no. 1, pp. 83-90. https://doi.org/10.1002/mds.10598
Payoux P, Boulanouar K, Sarramon C, Fabre N, Descombes S, Galitsky M et al. Cortical motor activation in akinetic schizoophrenic patients: A pilot functional MRI study. Movement Disorders. 2004 Jan;19(1):83-90. https://doi.org/10.1002/mds.10598
Payoux, Pierre ; Boulanouar, Kader ; Sarramon, Christine ; Fabre, Nelly ; Descombes, Sylvie ; Galitsky, Monique ; Thalamas, Claire ; Brefel-Courbon, Christine ; Sabatini, Umberto ; Manelfe, Claude ; Chollet, François ; Schmitt, Laurent ; Rascol, Oliver. / Cortical motor activation in akinetic schizoophrenic patients : A pilot functional MRI study. In: Movement Disorders. 2004 ; Vol. 19, No. 1. pp. 83-90.
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