Cortical motor overactivation in parkinsonian patients with L-dopa-induced peak-dose dyskinesia

O. Rascol, U. Sabatini, C. Brefel, N. Fabre, S. Rai, J. M. Senard, P. Celsis, G. Viallard, J. L. Montastruc, F. Chollet

Research output: Contribution to journalArticle

134 Citations (Scopus)

Abstract

We have studied the regional cerebral blood flow (rCBF) changes induced by the execution of a finger-to-thumb opposition motor task in the supplementary and primary motor cortex of two groups of parkinsonian patients on L-dopa medication, the first one without L-dopa induced dyskinesia (n = 23) and the other with moderate peak-dose dyskinesia (n = 15), and of a group of 14 normal subjects. Single photon emission tomography with i.v. 133Xe was used to measure the rCBF changes. The dyskinetic parkinsonian patients exhibited a pattern of response which was markedly different from those of the normal subjects and non-dyskinetic parkinsonian patients, with a significant overactivation in the supplementary motor area and the ipsi- and contralateral primary motor areas. These results are compatible with the hypothesis that an hyperkinetic abnormal involuntary movement, like L-dopa-induced peak dose dyskinesia, is due to a disinhibition of the primary and associated motor cortex secondary to an excessive outflow of the pallidothalamocortical motor loop.

Original languageEnglish
Pages (from-to)527-533
Number of pages7
JournalBrain
Volume121
Issue number3
DOIs
Publication statusPublished - Mar 1998

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Dyskinesias
Levodopa
Motor Cortex
Cerebrovascular Circulation
Regional Blood Flow
Thumb
Photons
Fingers
Tomography

Keywords

  • Abnormal involuntary movements
  • Parkinson's disease
  • Peak-dose dyskinesia
  • rCBF
  • Single photon emission tomography

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Rascol, O., Sabatini, U., Brefel, C., Fabre, N., Rai, S., Senard, J. M., ... Chollet, F. (1998). Cortical motor overactivation in parkinsonian patients with L-dopa-induced peak-dose dyskinesia. Brain, 121(3), 527-533. https://doi.org/10.1093/brain/121.3.527

Cortical motor overactivation in parkinsonian patients with L-dopa-induced peak-dose dyskinesia. / Rascol, O.; Sabatini, U.; Brefel, C.; Fabre, N.; Rai, S.; Senard, J. M.; Celsis, P.; Viallard, G.; Montastruc, J. L.; Chollet, F.

In: Brain, Vol. 121, No. 3, 03.1998, p. 527-533.

Research output: Contribution to journalArticle

Rascol, O, Sabatini, U, Brefel, C, Fabre, N, Rai, S, Senard, JM, Celsis, P, Viallard, G, Montastruc, JL & Chollet, F 1998, 'Cortical motor overactivation in parkinsonian patients with L-dopa-induced peak-dose dyskinesia', Brain, vol. 121, no. 3, pp. 527-533. https://doi.org/10.1093/brain/121.3.527
Rascol O, Sabatini U, Brefel C, Fabre N, Rai S, Senard JM et al. Cortical motor overactivation in parkinsonian patients with L-dopa-induced peak-dose dyskinesia. Brain. 1998 Mar;121(3):527-533. https://doi.org/10.1093/brain/121.3.527
Rascol, O. ; Sabatini, U. ; Brefel, C. ; Fabre, N. ; Rai, S. ; Senard, J. M. ; Celsis, P. ; Viallard, G. ; Montastruc, J. L. ; Chollet, F. / Cortical motor overactivation in parkinsonian patients with L-dopa-induced peak-dose dyskinesia. In: Brain. 1998 ; Vol. 121, No. 3. pp. 527-533.
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