Cortical motor overactivation in parkinsonian patients with L-dopa-induced peak-dose dyskinesia

O. Rascol, U. Sabatini, C. Brefel, N. Fabre, S. Rai, J. M. Senard, P. Celsis, G. Viallard, J. L. Montastruc, F. Chollet

Research output: Contribution to journalArticlepeer-review


We have studied the regional cerebral blood flow (rCBF) changes induced by the execution of a finger-to-thumb opposition motor task in the supplementary and primary motor cortex of two groups of parkinsonian patients on L-dopa medication, the first one without L-dopa induced dyskinesia (n = 23) and the other with moderate peak-dose dyskinesia (n = 15), and of a group of 14 normal subjects. Single photon emission tomography with i.v. 133Xe was used to measure the rCBF changes. The dyskinetic parkinsonian patients exhibited a pattern of response which was markedly different from those of the normal subjects and non-dyskinetic parkinsonian patients, with a significant overactivation in the supplementary motor area and the ipsi- and contralateral primary motor areas. These results are compatible with the hypothesis that an hyperkinetic abnormal involuntary movement, like L-dopa-induced peak dose dyskinesia, is due to a disinhibition of the primary and associated motor cortex secondary to an excessive outflow of the pallidothalamocortical motor loop.

Original languageEnglish
Pages (from-to)527-533
Number of pages7
Issue number3
Publication statusPublished - Mar 1998


  • Abnormal involuntary movements
  • Parkinson's disease
  • Peak-dose dyskinesia
  • rCBF
  • Single photon emission tomography

ASJC Scopus subject areas

  • Neuroscience(all)


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