Cortical motor reorganization in akinetic patients with Parkinson's disease. A functional MRI study

U. Sabatini, K. Boulanouar, N. Fabre, F. Martin, C. Carel, C. Colonnese, L. Bozzao, I. Berry, J. L. Montastruc, F. Chollet, O. Rascol

Research output: Contribution to journalArticle

Abstract

Using functional MRI (fMRI), we have studied the changes induced by the performance of a complex sequential motor task in the cortical areas of six akinetic patients with Parkinson's disease and six normal subjects. Compared with the normal subjects, the patients with Parkinson's disease exhibited a relatively decreased fMRI signal in the rostral part of the supplementary motor area (SMA) and in the right dorsolateral prefrontal cortex, as previously shown in PET studies. Concomitantly, the same patients exhibited a significant bilateral relative increase in fMRI signal in the primary sensorimotor cortex, lateral premotor cortex, inferior parietal cortex, caudal part of the SMA and anterior cingulate cortex. These fMRI data confirm that the frontal hypoactivation observed in patients with Parkinson's disease is restricted to the rostral part of the SMA and to the dorsolateral prefrontal cortex. These results also show that, apart from the lateral premotor and parietal cortices, increased fMRI signals can be found in other cortical motor areas of these patients, including the posterior SMA, the anterior cingulate cortex and the primary sensorimotor cortices, which are then likely to participate in the same putative attempt by the dopamine-denervated brain to recruit parallel motor circuits in order to overcome the functional deficit of the striatocortical motor loops.

Original languageEnglish
Pages (from-to)394-403
Number of pages10
JournalBrain
Volume123
Issue number2
Publication statusPublished - Feb 2000

Keywords

  • Akinesia
  • Cingulate cortex
  • fMRI
  • Motor reorganization
  • Parkinson's disease
  • Supplementary motor area

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Cortical motor reorganization in akinetic patients with Parkinson's disease. A functional MRI study'. Together they form a unique fingerprint.

  • Cite this

    Sabatini, U., Boulanouar, K., Fabre, N., Martin, F., Carel, C., Colonnese, C., Bozzao, L., Berry, I., Montastruc, J. L., Chollet, F., & Rascol, O. (2000). Cortical motor reorganization in akinetic patients with Parkinson's disease. A functional MRI study. Brain, 123(2), 394-403.