Cortical myoclonic tremor induced by fixation-off sensitivity: An unusual cause of insomnia

Laura Licchetta; Francesca Bisulli; Lorenzo Ferri; Gaetano Cantalupo; Lara Alvisi; Luca Vignatelli; Giuseppe Loddo; Federica Provini; Paolo Tinuper

doi:10.1212/WNL.0000000000006620

Cortical myoclonic tremor induced by fixation-off sensitivity: An unusual cause of insomnia

Laura Licchetta, Francesca Bisulli, Lorenzo Ferri, Gaetano Cantalupo, Lara Alvisi, Luca Vignatelli, Giuseppe Loddo, Federica Provini, Paolo Tinuper

Istituto Scienze Neurologiche

Research output: Contribution to journal › Article › peer-review

Abstract

Fixation-oﬀ sensitivity (FOS) refers to seizures or EEG abnormalities elicited by the elimination of central vision/ﬁxation, even in the presence of light.1 Typically, a paroxysmal discharge occurs within 1–3 seconds of eye closure, persists throughout the eye-closed state, and disappears immediately on eye opening.2
FOS occurs mainly in childhood occipital epilepsies.1 It has also been reported in generalized andfocalepilepsiesofstructural/unknownetiology,eyelidmyocloniawithabsences,andrarely in nonepileptic individuals.3
We describe a patient with FOS associated with cortical myoclonic tremor (CMT) so intense and severe at wake-sleep transition to cause sleep-onset insomnia as the main complaint.

Original language	English
Pages (from-to)	1061-1063
Number of pages	3
Journal	Neurology
Volume	91
Issue number	23
DOIs	https://doi.org/10.1212/WNL.0000000000006620
Publication status	Published - Dec 4 2018

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Cortical myoclonic tremor induced by fixation-off sensitivity : An unusual cause of insomnia. / Licchetta, Laura ; Bisulli, Francesca; Ferri, Lorenzo; Cantalupo, Gaetano; Alvisi, Lara; Vignatelli, Luca; Loddo, Giuseppe; Provini, Federica ; Tinuper, Paolo.

In: Neurology, Vol. 91, No. 23, 04.12.2018, p. 1061-1063.

Research output: Contribution to journal › Article › peer-review

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abstract = "Fixation-oﬀ sensitivity (FOS) refers to seizures or EEG abnormalities elicited by the elimination of central vision/ﬁxation, even in the presence of light.1 Typically, a paroxysmal discharge occurs within 1–3 seconds of eye closure, persists throughout the eye-closed state, and disappears immediately on eye opening.2FOS occurs mainly in childhood occipital epilepsies.1 It has also been reported in generalized andfocalepilepsiesofstructural/unknownetiology,eyelidmyocloniawithabsences,andrarely in nonepileptic individuals.3We describe a patient with FOS associated with cortical myoclonic tremor (CMT) so intense and severe at wake-sleep transition to cause sleep-onset insomnia as the main complaint.",

author = "Laura Licchetta and Francesca Bisulli and Lorenzo Ferri and Gaetano Cantalupo and Lara Alvisi and Luca Vignatelli and Giuseppe Loddo and Federica Provini and Paolo Tinuper",

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AU - Licchetta, Laura

AU - Bisulli, Francesca

AU - Ferri, Lorenzo

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AU - Alvisi, Lara

AU - Vignatelli, Luca

AU - Loddo, Giuseppe

AU - Provini, Federica

AU - Tinuper, Paolo

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