Cortical myoclonic tremor induced by fixation-off sensitivity: An unusual cause of insomnia

Laura Licchetta; Francesca Bisulli; Lorenzo Ferri; Gaetano Cantalupo; Lara Alvisi; Luca Vignatelli; Giuseppe Loddo; Federica Provini; Paolo Tinuper

doi:10.1212/WNL.0000000000006620

Cortical myoclonic tremor induced by fixation-off sensitivity: An unusual cause of insomnia

Laura Licchetta, Francesca Bisulli, Lorenzo Ferri, Gaetano Cantalupo, Lara Alvisi, Luca Vignatelli, Giuseppe Loddo, Federica Provini, Paolo Tinuper

Istituto Scienze Neurologiche

Research output: Contribution to journal › Article › peer-review

Abstract

Fixation-oﬀ sensitivity (FOS) refers to seizures or EEG abnormalities elicited by the elimination of central vision/ﬁxation, even in the presence of light.1 Typically, a paroxysmal discharge occurs within 1–3 seconds of eye closure, persists throughout the eye-closed state, and disappears immediately on eye opening.2
FOS occurs mainly in childhood occipital epilepsies.1 It has also been reported in generalized andfocalepilepsiesofstructural/unknownetiology,eyelidmyocloniawithabsences,andrarely in nonepileptic individuals.3
We describe a patient with FOS associated with cortical myoclonic tremor (CMT) so intense and severe at wake-sleep transition to cause sleep-onset insomnia as the main complaint.

Original language	English
Pages (from-to)	1061-1063
Number of pages	3
Journal	Neurology
Volume	91
Issue number	23
DOIs	https://doi.org/10.1212/WNL.0000000000006620
Publication status	Published - Dec 4 2018

Access to Document

10.1212/WNL.0000000000006620

Cite this

@article{0d8678cd6f834287a5f3344ac835a1f8,

title = "Cortical myoclonic tremor induced by fixation-off sensitivity: An unusual cause of insomnia",

abstract = "Fixation-oﬀ sensitivity (FOS) refers to seizures or EEG abnormalities elicited by the elimination of central vision/ﬁxation, even in the presence of light.1 Typically, a paroxysmal discharge occurs within 1–3 seconds of eye closure, persists throughout the eye-closed state, and disappears immediately on eye opening.2FOS occurs mainly in childhood occipital epilepsies.1 It has also been reported in generalized andfocalepilepsiesofstructural/unknownetiology,eyelidmyocloniawithabsences,andrarely in nonepileptic individuals.3We describe a patient with FOS associated with cortical myoclonic tremor (CMT) so intense and severe at wake-sleep transition to cause sleep-onset insomnia as the main complaint.",

author = "Laura Licchetta and Francesca Bisulli and Lorenzo Ferri and Gaetano Cantalupo and Lara Alvisi and Luca Vignatelli and Giuseppe Loddo and Federica Provini and Paolo Tinuper",

note = "Ricercatori distaccati presso IRCCS a seguito Convenzione esclusiva con Universit{\`a} di Bologna (Licchetta Laura, Bisulli Francesca, Alvisi Lara, Provini Federica,Tinuper Paolo). Richiesto CORRIGENDUM per modifica di affiliazione. ",

year = "2018",

month = dec,

day = "4",

doi = "10.1212/WNL.0000000000006620",

language = "English",

volume = "91",

pages = "1061--1063",

journal = "Neurology",

issn = "0028-3878",

publisher = "Lippincott Williams and Wilkins",

number = "23",

}

TY - JOUR

T1 - Cortical myoclonic tremor induced by fixation-off sensitivity

T2 - An unusual cause of insomnia

AU - Licchetta, Laura

AU - Bisulli, Francesca

AU - Ferri, Lorenzo

AU - Cantalupo, Gaetano

AU - Alvisi, Lara

AU - Vignatelli, Luca

AU - Loddo, Giuseppe

AU - Provini, Federica

AU - Tinuper, Paolo

N1 - Ricercatori distaccati presso IRCCS a seguito Convenzione esclusiva con Università di Bologna (Licchetta Laura, Bisulli Francesca, Alvisi Lara, Provini Federica,Tinuper Paolo). Richiesto CORRIGENDUM per modifica di affiliazione.

PY - 2018/12/4

Y1 - 2018/12/4

N2 - Fixation-oﬀ sensitivity (FOS) refers to seizures or EEG abnormalities elicited by the elimination of central vision/ﬁxation, even in the presence of light.1 Typically, a paroxysmal discharge occurs within 1–3 seconds of eye closure, persists throughout the eye-closed state, and disappears immediately on eye opening.2FOS occurs mainly in childhood occipital epilepsies.1 It has also been reported in generalized andfocalepilepsiesofstructural/unknownetiology,eyelidmyocloniawithabsences,andrarely in nonepileptic individuals.3We describe a patient with FOS associated with cortical myoclonic tremor (CMT) so intense and severe at wake-sleep transition to cause sleep-onset insomnia as the main complaint.

AB - Fixation-oﬀ sensitivity (FOS) refers to seizures or EEG abnormalities elicited by the elimination of central vision/ﬁxation, even in the presence of light.1 Typically, a paroxysmal discharge occurs within 1–3 seconds of eye closure, persists throughout the eye-closed state, and disappears immediately on eye opening.2FOS occurs mainly in childhood occipital epilepsies.1 It has also been reported in generalized andfocalepilepsiesofstructural/unknownetiology,eyelidmyocloniawithabsences,andrarely in nonepileptic individuals.3We describe a patient with FOS associated with cortical myoclonic tremor (CMT) so intense and severe at wake-sleep transition to cause sleep-onset insomnia as the main complaint.

U2 - 10.1212/WNL.0000000000006620

DO - 10.1212/WNL.0000000000006620

M3 - Article

C2 - 30413630

VL - 91

SP - 1061

EP - 1063

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 23

ER -

Cortical myoclonic tremor induced by fixation-off sensitivity: An unusual cause of insomnia

Abstract

Access to Document

Fingerprint

Cite this