Cortical myoclonic tremor induced by fixation-off sensitivity: An unusual cause of insomnia

Laura Licchetta, Francesca Bisulli, Lorenzo Ferri, Gaetano Cantalupo, Lara Alvisi, Luca Vignatelli, Giuseppe Loddo, Federica Provini, Paolo Tinuper

Research output: Contribution to journalArticlepeer-review

Abstract

Fixation-off sensitivity (FOS) refers to seizures or EEG abnormalities elicited by the elimination of central vision/fixation, even in the presence of light.1 Typically, a paroxysmal discharge occurs within 1–3 seconds of eye closure, persists throughout the eye-closed state, and disappears immediately on eye opening.2
FOS occurs mainly in childhood occipital epilepsies.1 It has also been reported in generalized andfocalepilepsiesofstructural/unknownetiology,eyelidmyocloniawithabsences,andrarely in nonepileptic individuals.3
We describe a patient with FOS associated with cortical myoclonic tremor (CMT) so intense and severe at wake-sleep transition to cause sleep-onset insomnia as the main complaint.
Original languageEnglish
Pages (from-to)1061-1063
Number of pages3
JournalNeurology
Volume91
Issue number23
DOIs
Publication statusPublished - Dec 4 2018

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