TY - JOUR
T1 - Cortical network modularity changes along the course of frontotemporal and Alzheimer's dementing diseases
AU - FTD Italian study group-SINDEM
AU - Franciotti, Raffaella
AU - Moretti, Davide V.
AU - Benussi, Alberto
AU - Ferri, Laura
AU - Russo, Mirella
AU - Carrarini, Claudia
AU - Barbone, Filomena
AU - Arnaldi, Dario
AU - Falasca, Nicola W.
AU - Koch, Giacomo
AU - Cagnin, Annachiara
AU - Nobili, Flavio M.
AU - Babiloni, Claudio
AU - Borroni, Barbara
AU - Padovani, Alessandro
AU - Onofrj, Marco
AU - Bonanni, Laura
N1 - Funding Information:
Franciotti R has nothing to disclose. Moretti DV has nothing to disclose Benussi A has nothing to disclose. Ferri L has nothing to disclose. Russo M has nothing to disclose. Carrarini C has nothing to disclose. Barbone F has nothing to disclose. Arnaldi D has nothing to disclose. Falasca NW has nothing to disclose. Koch G has nothing to disclose. Cagnin A has nothing to disclose. Nobili F has received fees from G.E. Healthcare for teaching courses, from BIAL for consultation and from Roche for board participation. Babiloni C has nothing to disclose. Borroni B has nothing to disclose. Padovani A has nothing to disclose. Onofrj M has served on the scientific advisory boards of GlaxoSmithKline, Novartis, Lundbeck, Eisai, Valeant, Medtronic, and Newron; has received speaker honoraria from Zambon, the World Parkinson Congress, the Movement Disorder Society, and the Atypical Dementias congress; publishing royalties from Springer; was an invited guest and lecturer for the Mental Disorders in Parkinson Disease Congress; serves on the editorial board of Medicine (Baltimore) and Frontiers in Neurology; has been employed as a speaker for Boehringer Ingelheim, GlaxoSmithKline, UCB, and Zambon; and has received research support from the Italian Ministry of Health and the Italian Ministry of Education. Bonanni L: Received unrelated national grants from the Italian Ministry of Health and from Mentis cura, Oslo srl; fees from G.E. Healthcare for teaching courses.
Publisher Copyright:
© 2021
PY - 2022/2
Y1 - 2022/2
N2 - Cortical network modularity underpins cognitive functions, so we hypothesized its progressive derangement along the course of frontotemporal (FTD) and Alzheimer's (AD) dementing diseases. EEG was recorded in 18 FTD, 18 AD, and 20 healthy controls (HC). In the FTD and AD patients, the EEG recordings were performed at the prodromal stage of dementia, at the onset of dementia, and three years after the onset of dementia. HC underwent three EEG recordings at 2–3-year time interval. Information flows underlying EEG activity recorded at electrode pairs were estimated by means of Mutual Information (MI) analysis. The functional organization of the cortical network was modelled by means of the Graph theory analysis on MI adjacency matrices. Graph theory analysis showed that the main hub of HC (Parietal area) was lost in FTD patients at onset of dementia, substituted by provincial hubs in frontal leads. No changes in global network organization were found in AD. Despite a progressive cognitive impairment during the FTD and AD progression, only the FTD patients showed a derangement in the cortical network modularity, possibly due to dysfunctions in frontal functional connectivity.
AB - Cortical network modularity underpins cognitive functions, so we hypothesized its progressive derangement along the course of frontotemporal (FTD) and Alzheimer's (AD) dementing diseases. EEG was recorded in 18 FTD, 18 AD, and 20 healthy controls (HC). In the FTD and AD patients, the EEG recordings were performed at the prodromal stage of dementia, at the onset of dementia, and three years after the onset of dementia. HC underwent three EEG recordings at 2–3-year time interval. Information flows underlying EEG activity recorded at electrode pairs were estimated by means of Mutual Information (MI) analysis. The functional organization of the cortical network was modelled by means of the Graph theory analysis on MI adjacency matrices. Graph theory analysis showed that the main hub of HC (Parietal area) was lost in FTD patients at onset of dementia, substituted by provincial hubs in frontal leads. No changes in global network organization were found in AD. Despite a progressive cognitive impairment during the FTD and AD progression, only the FTD patients showed a derangement in the cortical network modularity, possibly due to dysfunctions in frontal functional connectivity.
KW - Alzheimer's dementia
KW - Frontotemporal dementia
KW - Functional connectivity
KW - Graph theory
KW - Mutual information
KW - Resting state Electroencephalography
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U2 - 10.1016/j.neurobiolaging.2021.10.016
DO - 10.1016/j.neurobiolaging.2021.10.016
M3 - Article
AN - SCOPUS:85119997610
VL - 110
SP - 37
EP - 46
JO - Neurobiology of Aging
JF - Neurobiology of Aging
SN - 0197-4580
ER -