Cortical network modularity changes along the course of frontotemporal and Alzheimer's dementing diseases

FTD Italian study group-SINDEM

Research output: Contribution to journalArticlepeer-review

Abstract

Cortical network modularity underpins cognitive functions, so we hypothesized its progressive derangement along the course of frontotemporal (FTD) and Alzheimer's (AD) dementing diseases. EEG was recorded in 18 FTD, 18 AD, and 20 healthy controls (HC). In the FTD and AD patients, the EEG recordings were performed at the prodromal stage of dementia, at the onset of dementia, and three years after the onset of dementia. HC underwent three EEG recordings at 2–3-year time interval. Information flows underlying EEG activity recorded at electrode pairs were estimated by means of Mutual Information (MI) analysis. The functional organization of the cortical network was modelled by means of the Graph theory analysis on MI adjacency matrices. Graph theory analysis showed that the main hub of HC (Parietal area) was lost in FTD patients at onset of dementia, substituted by provincial hubs in frontal leads. No changes in global network organization were found in AD. Despite a progressive cognitive impairment during the FTD and AD progression, only the FTD patients showed a derangement in the cortical network modularity, possibly due to dysfunctions in frontal functional connectivity.

Original languageEnglish
Pages (from-to)37-46
Number of pages10
JournalNeurobiology of Aging
Volume110
DOIs
Publication statusPublished - Feb 2022

Keywords

  • Alzheimer's dementia
  • Frontotemporal dementia
  • Functional connectivity
  • Graph theory
  • Mutual information
  • Resting state Electroencephalography

ASJC Scopus subject areas

  • Neuroscience(all)
  • Ageing
  • Developmental Biology
  • Clinical Neurology
  • Geriatrics and Gerontology

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