Cortical neuromodulation modifies cerebral vasomotor reactivity

Fabrizio Vernieri, Giovanni Assenza, Paola Maggio, Francesco Tibuzzi, Filippo Zappasodi, Claudia Altamura, Marzia Corbetto, Laura Trotta, Paola Palazzo, Matilde Ercolani, Franca Tecchio, Paolo Maria Rossini

Research output: Contribution to journalArticlepeer-review


Background and Purpose-: Cerebral vasomotor reactivity (VMR) is a capability of cerebral vessels to dilate in response to hypercapnia. Transcranial direct current stimulation (tDCS) effects on cerebral hemodynamics have been poorly studied. Methods and Results-: Ten healthy subjects underwent anodal/cathodal tDCS on the left motor cortex. Before and after tDCS, VMR assessment by transcranial Doppler and an electrocardiogram were performed. Normalized low-frequency band power of heart rate variability and its reactivity from basal to VMR condition (LFNreact) were estimated as relative markers of sympathetic activation. tDCS exerted a polarity-specific effect on both VMR (P=0.0001) and LFNreact (P=0.001). Anodal tDCS decreased VMR by 3.4%/mm Hg CO2 bilaterally and increased LFNreact, whereas cathodal tDCS increased VMR by 0.8%/mm Hg CO2 bilaterally and reduced LFNreact. Conclusions-: Cerebral VMR is modified by tDCS. Based on the consensual changes with heart rate variability, we can hypothesize that the sympathetic nervous system could modulate the bihemispheric modification of VMR. Further studies are needed to confirm this hypothesis.

Original languageEnglish
Pages (from-to)2087-2090
Number of pages4
Issue number9
Publication statusPublished - Sep 2010


  • cerebral hemodynamics
  • heart rate variability
  • stroke
  • transcranial direct current stimulation
  • transcranial Doppler

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialised Nursing
  • Medicine(all)


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