TY - JOUR
T1 - Cortical Pathophysiology and Clinical Neurologic Abnormalities in Acute Cerebral Ischemia
T2 - A Serial Study with Single Photon Emission Computed Tomography
AU - Rango, Mario
AU - Candelise, Livia
AU - Scarlato, Guglielmo
AU - Perani, Daniela
AU - Messa, Cristina
AU - Fazio, Ferrucio
AU - Canal, Nicola
AU - Franceschi, Massimo
PY - 1989
Y1 - 1989
N2 - We studied brain cortical radioactive tracer activity in a consecutive series of nine patients with acute hemispheric ischemic stroke at their first cerebral ischemic episode. Results from N,N,N-trimethyl-N- (2-hydroxy-3-methyl-5-[123-l]iodobenzyl)-1,3 propanediamine-2HCI (four patients) and technetium Tc 99m hexamethylpropyleneamine oxime (five patients) single photon emission computed tomographic studies were compared with x-raycomputed tomography (CT) and clinical findings within the first 48 hours, on day 10, and on day 30 after the clinical ictus. Cortical hypoactivity agreeing with the clinical findings was found on all initial scans but not in the follow-up studies. Cortical activity on the affected side in patients with stroke was significantly lower when compared with cortical activity in sex- and age-matched controls (n = 21). Computed tomography (with contrast) was less sensitive in detecting the ischemic lesions. These studies demonstrate that in the acute phase of stroke there is a single photon emission computed tomographic cortical disturbance that agrees with clinical findings, even when computed tomography scan infarction is limited to subcortical structures.
AB - We studied brain cortical radioactive tracer activity in a consecutive series of nine patients with acute hemispheric ischemic stroke at their first cerebral ischemic episode. Results from N,N,N-trimethyl-N- (2-hydroxy-3-methyl-5-[123-l]iodobenzyl)-1,3 propanediamine-2HCI (four patients) and technetium Tc 99m hexamethylpropyleneamine oxime (five patients) single photon emission computed tomographic studies were compared with x-raycomputed tomography (CT) and clinical findings within the first 48 hours, on day 10, and on day 30 after the clinical ictus. Cortical hypoactivity agreeing with the clinical findings was found on all initial scans but not in the follow-up studies. Cortical activity on the affected side in patients with stroke was significantly lower when compared with cortical activity in sex- and age-matched controls (n = 21). Computed tomography (with contrast) was less sensitive in detecting the ischemic lesions. These studies demonstrate that in the acute phase of stroke there is a single photon emission computed tomographic cortical disturbance that agrees with clinical findings, even when computed tomography scan infarction is limited to subcortical structures.
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U2 - 10.1001/archneur.1989.00520480060021
DO - 10.1001/archneur.1989.00520480060021
M3 - Article
C2 - 2590016
AN - SCOPUS:0024829885
VL - 46
SP - 1318
EP - 1322
JO - Archives of Neurology
JF - Archives of Neurology
SN - 0003-9942
IS - 12
ER -