Cortical reorganization in an astronaut’s brain after long-duration spaceflight

Athena Demertzi, Angelique van Ombergen, Elena Tomilovskaya, Ben Jeurissen, Ekaterina Pechenkova, Carol Di Perri, Liudmila Litvinova, Enrico Amico, Alena Rumshiskaya, Ilya Rukavishnikov, Jan Sijbers, Valentin Sinitsyn, Inessa B. Kozlovskaya, Stefan Sunaert, Paul M. Parizel, Paul H. van de Heyning, Steven S L Laureys, Floris L. Wuyts

Research output: Contribution to journalArticle

Abstract

To date, hampered physiological function after exposure to microgravity has been primarily attributed to deprived peripheral neuro-sensory systems. For the first time, this study elucidates alterations in human brain function after long-duration spaceflight. More specifically, we found significant differences in resting-state functional connectivity between motor cortex and cerebellum, as well as changes within the default mode network. In addition, the cosmonaut showed changes in the supplementary motor areas during a motor imagery task. These results highlight the underlying neural basis for the observed physiological deconditioning due to spaceflight and are relevant for future interplanetary missions and vestibular patients.

Original languageEnglish
JournalBrain Structure and Function
DOIs
Publication statusAccepted/In press - May 12 2015

Fingerprint

Astronauts
Space Flight
Motor Cortex
Weightlessness
Time and Motion Studies
Imagery (Psychotherapy)
Brain
Cerebellum

Keywords

  • Cortical reorganization
  • Functional MRI
  • Microgravity
  • Motor behavior
  • Vestibular cortex

ASJC Scopus subject areas

  • Neuroscience(all)
  • Anatomy
  • Histology

Cite this

Demertzi, A., van Ombergen, A., Tomilovskaya, E., Jeurissen, B., Pechenkova, E., Di Perri, C., ... Wuyts, F. L. (Accepted/In press). Cortical reorganization in an astronaut’s brain after long-duration spaceflight. Brain Structure and Function. https://doi.org/10.1007/s00429-015-1054-3

Cortical reorganization in an astronaut’s brain after long-duration spaceflight. / Demertzi, Athena; van Ombergen, Angelique; Tomilovskaya, Elena; Jeurissen, Ben; Pechenkova, Ekaterina; Di Perri, Carol; Litvinova, Liudmila; Amico, Enrico; Rumshiskaya, Alena; Rukavishnikov, Ilya; Sijbers, Jan; Sinitsyn, Valentin; Kozlovskaya, Inessa B.; Sunaert, Stefan; Parizel, Paul M.; van de Heyning, Paul H.; Laureys, Steven S L; Wuyts, Floris L.

In: Brain Structure and Function, 12.05.2015.

Research output: Contribution to journalArticle

Demertzi, A, van Ombergen, A, Tomilovskaya, E, Jeurissen, B, Pechenkova, E, Di Perri, C, Litvinova, L, Amico, E, Rumshiskaya, A, Rukavishnikov, I, Sijbers, J, Sinitsyn, V, Kozlovskaya, IB, Sunaert, S, Parizel, PM, van de Heyning, PH, Laureys, SSL & Wuyts, FL 2015, 'Cortical reorganization in an astronaut’s brain after long-duration spaceflight', Brain Structure and Function. https://doi.org/10.1007/s00429-015-1054-3
Demertzi A, van Ombergen A, Tomilovskaya E, Jeurissen B, Pechenkova E, Di Perri C et al. Cortical reorganization in an astronaut’s brain after long-duration spaceflight. Brain Structure and Function. 2015 May 12. https://doi.org/10.1007/s00429-015-1054-3
Demertzi, Athena ; van Ombergen, Angelique ; Tomilovskaya, Elena ; Jeurissen, Ben ; Pechenkova, Ekaterina ; Di Perri, Carol ; Litvinova, Liudmila ; Amico, Enrico ; Rumshiskaya, Alena ; Rukavishnikov, Ilya ; Sijbers, Jan ; Sinitsyn, Valentin ; Kozlovskaya, Inessa B. ; Sunaert, Stefan ; Parizel, Paul M. ; van de Heyning, Paul H. ; Laureys, Steven S L ; Wuyts, Floris L. / Cortical reorganization in an astronaut’s brain after long-duration spaceflight. In: Brain Structure and Function. 2015.
@article{0c3a0e98c1b441319e3001fa843dbc8b,
title = "Cortical reorganization in an astronaut’s brain after long-duration spaceflight",
abstract = "To date, hampered physiological function after exposure to microgravity has been primarily attributed to deprived peripheral neuro-sensory systems. For the first time, this study elucidates alterations in human brain function after long-duration spaceflight. More specifically, we found significant differences in resting-state functional connectivity between motor cortex and cerebellum, as well as changes within the default mode network. In addition, the cosmonaut showed changes in the supplementary motor areas during a motor imagery task. These results highlight the underlying neural basis for the observed physiological deconditioning due to spaceflight and are relevant for future interplanetary missions and vestibular patients.",
keywords = "Cortical reorganization, Functional MRI, Microgravity, Motor behavior, Vestibular cortex",
author = "Athena Demertzi and {van Ombergen}, Angelique and Elena Tomilovskaya and Ben Jeurissen and Ekaterina Pechenkova and {Di Perri}, Carol and Liudmila Litvinova and Enrico Amico and Alena Rumshiskaya and Ilya Rukavishnikov and Jan Sijbers and Valentin Sinitsyn and Kozlovskaya, {Inessa B.} and Stefan Sunaert and Parizel, {Paul M.} and {van de Heyning}, {Paul H.} and Laureys, {Steven S L} and Wuyts, {Floris L.}",
year = "2015",
month = "5",
day = "12",
doi = "10.1007/s00429-015-1054-3",
language = "English",
journal = "Zeitschrift fur Anatomie und Entwicklungsgeschichte",
issn = "0177-5154",
publisher = "Springer Verlag",

}

TY - JOUR

T1 - Cortical reorganization in an astronaut’s brain after long-duration spaceflight

AU - Demertzi, Athena

AU - van Ombergen, Angelique

AU - Tomilovskaya, Elena

AU - Jeurissen, Ben

AU - Pechenkova, Ekaterina

AU - Di Perri, Carol

AU - Litvinova, Liudmila

AU - Amico, Enrico

AU - Rumshiskaya, Alena

AU - Rukavishnikov, Ilya

AU - Sijbers, Jan

AU - Sinitsyn, Valentin

AU - Kozlovskaya, Inessa B.

AU - Sunaert, Stefan

AU - Parizel, Paul M.

AU - van de Heyning, Paul H.

AU - Laureys, Steven S L

AU - Wuyts, Floris L.

PY - 2015/5/12

Y1 - 2015/5/12

N2 - To date, hampered physiological function after exposure to microgravity has been primarily attributed to deprived peripheral neuro-sensory systems. For the first time, this study elucidates alterations in human brain function after long-duration spaceflight. More specifically, we found significant differences in resting-state functional connectivity between motor cortex and cerebellum, as well as changes within the default mode network. In addition, the cosmonaut showed changes in the supplementary motor areas during a motor imagery task. These results highlight the underlying neural basis for the observed physiological deconditioning due to spaceflight and are relevant for future interplanetary missions and vestibular patients.

AB - To date, hampered physiological function after exposure to microgravity has been primarily attributed to deprived peripheral neuro-sensory systems. For the first time, this study elucidates alterations in human brain function after long-duration spaceflight. More specifically, we found significant differences in resting-state functional connectivity between motor cortex and cerebellum, as well as changes within the default mode network. In addition, the cosmonaut showed changes in the supplementary motor areas during a motor imagery task. These results highlight the underlying neural basis for the observed physiological deconditioning due to spaceflight and are relevant for future interplanetary missions and vestibular patients.

KW - Cortical reorganization

KW - Functional MRI

KW - Microgravity

KW - Motor behavior

KW - Vestibular cortex

UR - http://www.scopus.com/inward/record.url?scp=84929180161&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84929180161&partnerID=8YFLogxK

U2 - 10.1007/s00429-015-1054-3

DO - 10.1007/s00429-015-1054-3

M3 - Article

AN - SCOPUS:84929180161

JO - Zeitschrift fur Anatomie und Entwicklungsgeschichte

JF - Zeitschrift fur Anatomie und Entwicklungsgeschichte

SN - 0177-5154

ER -