Cortical reorganization in multiple sclerosis after intrathecal baclofen therapy

S. Guerrera, R. Morabito, A. Baglieri, F. Corallo, R. Ciurleo, R. De Luca, S. De Salvo, M. A. Marino, L. Spadaro, F. Timpano, P. Bramanti, S. Marino

Research output: Contribution to journalArticlepeer-review


Our objective was to assess the role of Intrathecal Baclofen Therapy (ITB) in the cortical reorganization in a patient affected by multiple sclerosis (MS) undergoing physical therapy. We reported a case of a woman affected by MS and severe spasticity, who performed an fMRI examination, before and after the ITB implantation. The subject showed controlateral motor cortex activation after motor task. After a month of ITB implantation, patient showed ipsilateral and controlateral motor cortex activation although with a broader extension. fMRI examination supported the hypothesis of a central influence in patients who undergo physiotherapy and therapy with ITB.

Original languageEnglish
Pages (from-to)225-229
Number of pages5
Issue number2
Publication statusPublished - Mar 2014


  • Functional magnetic resonance
  • Intrathecal baclofen therapy
  • Multiple sclerosis

ASJC Scopus subject areas

  • Clinical Neurology
  • Arts and Humanities (miscellaneous)


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