Cortical sources of resting state EEG rhythms are abnormal in dyslexic children

Claudio Babiloni, Giacomo Stella, Paola Buffo, Fabrizio Vecchio, Paolo Onorati, Chiara Muratori, Silvia Miano, Flavia Gheller, Laura Antonaci, Giorgio Albertini, Paolo M. Rossini

Research output: Contribution to journalArticle

Abstract

Objective: Previous studies have been inconclusive whether dominant resting state alpha rhythms differ in amplitude in dyslexic subjects when compared to control subjects, being these rhythms considered as a reflection of effective cortical neural synchronization and cognition. Here we used a validated EEG source estimation to test the hypothesis that resting state alpha rhythms are abnormal in dyslexic subjects and are related to reading deficits. Methods: Eyes-closed resting state electroencephalographic (EEG) data were recorded in 26 dyslexics (12 males, mean age of 11. years ± 0.5. standard error of mean, SEM) and 11 age-matched normal control subjects (8 males, mean age of 11. years ± 0.7. SEM). EEG rhythms of interest, based on individual alpha frequency peak, were the following: about 2-4. Hz (delta), 4-6. Hz (theta), 6-8. Hz (alpha 1), 8-10. Hz (alpha 2), and 10-12. Hz (alpha 3). For the higher frequencies, we selected beta 1 (13-20. Hz), beta 2 (20-30. Hz), and gamma (30-40. Hz). Cortical EEG sources were estimated by low resolution electromagnetic tomography (LORETA). LORETA solutions were normalized across all voxels and frequencies. Results: Compared to the control children, the dyslexics showed lower amplitude of parietal, occipital, and temporal alpha 2 and alpha 3 sources. In the dyslexics, some of these sources were correlated to reading time of pseudo-words (parietal alpha 2, r=. -0.56, p=. 0.02; parietal alpha 3, r=. -0.58, p=. 0.02; temporal alpha 3, r=. -0.57, p=. 0.02); the higher the alpha power, the shorter the reading time. Conclusions: Dyslexic children are characterized by limited abnormalities of resting state EEG rhythms as to topography (posterior regions) and frequency (alpha), which were related to phonological encoding (pseudo-words reading). Significance: Dyslexia may be associated to some functional impairment of cortical neuronal synchronization mechanisms involved in the resting state condition.

Original languageEnglish
Pages (from-to)2384-2391
Number of pages8
JournalClinical Neurophysiology
Volume123
Issue number12
DOIs
Publication statusPublished - Dec 2012

Fingerprint

Reading
Cortical Synchronization
Alpha Rhythm
Electromagnetic Phenomena
Tomography
Dyslexia
Cognition

Keywords

  • Alpha
  • Brain rhythms
  • Dyslexic subjects
  • Individual alpha frequency (IAF)
  • Low-resolution brain electromagnetic source tomography (LORETA)
  • Resting-state electroencephalography (EEG)

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Physiology (medical)
  • Sensory Systems

Cite this

Cortical sources of resting state EEG rhythms are abnormal in dyslexic children. / Babiloni, Claudio; Stella, Giacomo; Buffo, Paola; Vecchio, Fabrizio; Onorati, Paolo; Muratori, Chiara; Miano, Silvia; Gheller, Flavia; Antonaci, Laura; Albertini, Giorgio; Rossini, Paolo M.

In: Clinical Neurophysiology, Vol. 123, No. 12, 12.2012, p. 2384-2391.

Research output: Contribution to journalArticle

Babiloni, C, Stella, G, Buffo, P, Vecchio, F, Onorati, P, Muratori, C, Miano, S, Gheller, F, Antonaci, L, Albertini, G & Rossini, PM 2012, 'Cortical sources of resting state EEG rhythms are abnormal in dyslexic children', Clinical Neurophysiology, vol. 123, no. 12, pp. 2384-2391. https://doi.org/10.1016/j.clinph.2012.05.002
Babiloni, Claudio ; Stella, Giacomo ; Buffo, Paola ; Vecchio, Fabrizio ; Onorati, Paolo ; Muratori, Chiara ; Miano, Silvia ; Gheller, Flavia ; Antonaci, Laura ; Albertini, Giorgio ; Rossini, Paolo M. / Cortical sources of resting state EEG rhythms are abnormal in dyslexic children. In: Clinical Neurophysiology. 2012 ; Vol. 123, No. 12. pp. 2384-2391.
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AU - Babiloni, Claudio

AU - Stella, Giacomo

AU - Buffo, Paola

AU - Vecchio, Fabrizio

AU - Onorati, Paolo

AU - Muratori, Chiara

AU - Miano, Silvia

AU - Gheller, Flavia

AU - Antonaci, Laura

AU - Albertini, Giorgio

AU - Rossini, Paolo M.

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N2 - Objective: Previous studies have been inconclusive whether dominant resting state alpha rhythms differ in amplitude in dyslexic subjects when compared to control subjects, being these rhythms considered as a reflection of effective cortical neural synchronization and cognition. Here we used a validated EEG source estimation to test the hypothesis that resting state alpha rhythms are abnormal in dyslexic subjects and are related to reading deficits. Methods: Eyes-closed resting state electroencephalographic (EEG) data were recorded in 26 dyslexics (12 males, mean age of 11. years ± 0.5. standard error of mean, SEM) and 11 age-matched normal control subjects (8 males, mean age of 11. years ± 0.7. SEM). EEG rhythms of interest, based on individual alpha frequency peak, were the following: about 2-4. Hz (delta), 4-6. Hz (theta), 6-8. Hz (alpha 1), 8-10. Hz (alpha 2), and 10-12. Hz (alpha 3). For the higher frequencies, we selected beta 1 (13-20. Hz), beta 2 (20-30. Hz), and gamma (30-40. Hz). Cortical EEG sources were estimated by low resolution electromagnetic tomography (LORETA). LORETA solutions were normalized across all voxels and frequencies. Results: Compared to the control children, the dyslexics showed lower amplitude of parietal, occipital, and temporal alpha 2 and alpha 3 sources. In the dyslexics, some of these sources were correlated to reading time of pseudo-words (parietal alpha 2, r=. -0.56, p=. 0.02; parietal alpha 3, r=. -0.58, p=. 0.02; temporal alpha 3, r=. -0.57, p=. 0.02); the higher the alpha power, the shorter the reading time. Conclusions: Dyslexic children are characterized by limited abnormalities of resting state EEG rhythms as to topography (posterior regions) and frequency (alpha), which were related to phonological encoding (pseudo-words reading). Significance: Dyslexia may be associated to some functional impairment of cortical neuronal synchronization mechanisms involved in the resting state condition.

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