TY - JOUR
T1 - Cortical sources of resting-state EEG rhythms are abnormal in naïve HIV subjects
AU - Babiloni, Claudio
AU - Vecchio, Fabrizio
AU - Buffo, Paola
AU - Onorati, Paolo
AU - Muratori, Chiara
AU - Ferracuti, Stefano
AU - Roma, Paolo
AU - Battuello, Michele
AU - Donato, Nicole
AU - Pellegrini, Paola
AU - Di Campli, Francesco
AU - Gianserra, Laura
AU - Teti, Elisabetta
AU - Aceti, Antonio
AU - Rossini, Paolo M.
AU - Pennica, Alfredo
PY - 2012/11
Y1 - 2012/11
N2 - Objective: The aim of the study was to test the hypothesis that cortical sources of resting-state electroencephalographic (EEG) rhythms show peculiar frequency/spatial features in naïve human subjects with human immunodeficiency virus (HIV) compared to healthy control subjects. Methods: Resting-state eyes-closed EEG data were recorded in 18 naïve HIV subjects (15 males; mean age 39. years ± 2.0 standard error of mean, SEM) and in 18 age-matched cognitively normal subjects (15 males; 38.7. years ± 2.2 SEM). EEG rhythms of interest were delta (2-4. Hz), theta (4-8. Hz), alpha1 (8-10. Hz), alpha2 (10-12. Hz), beta1 (13-20. Hz) and beta2 (20-30. Hz). Cortical EEG sources were estimated by normalised, low-resolution electromagnetic tomography (LORETA). Results: Mini Mental State Evaluation (MMSE) score was lower in HIV (26.5 ± 0.7 SEM) than in healthy (29.2 ± 0.5 SEM) subjects (p<0.05). Central and parietal delta sources showed higher amplitude in the HIV than in control subjects. Furthermore, topographically widespread, cortical sources of resting-state alpha rhythms were lower in amplitude in HIV subjects than in control subjects. Conclusions: The present results suggest that topography and frequency of the cortical sources of resting-state EEG rhythms can distinguish groups of HIV and control subjects. Significance: These results encourage future studies in an enlarged cohort of HIV subjects to test the hypothesis that the present methodological approach provides clinically useful information for an early detection of the effect of HIV infection on brain and cognitive functions.
AB - Objective: The aim of the study was to test the hypothesis that cortical sources of resting-state electroencephalographic (EEG) rhythms show peculiar frequency/spatial features in naïve human subjects with human immunodeficiency virus (HIV) compared to healthy control subjects. Methods: Resting-state eyes-closed EEG data were recorded in 18 naïve HIV subjects (15 males; mean age 39. years ± 2.0 standard error of mean, SEM) and in 18 age-matched cognitively normal subjects (15 males; 38.7. years ± 2.2 SEM). EEG rhythms of interest were delta (2-4. Hz), theta (4-8. Hz), alpha1 (8-10. Hz), alpha2 (10-12. Hz), beta1 (13-20. Hz) and beta2 (20-30. Hz). Cortical EEG sources were estimated by normalised, low-resolution electromagnetic tomography (LORETA). Results: Mini Mental State Evaluation (MMSE) score was lower in HIV (26.5 ± 0.7 SEM) than in healthy (29.2 ± 0.5 SEM) subjects (p<0.05). Central and parietal delta sources showed higher amplitude in the HIV than in control subjects. Furthermore, topographically widespread, cortical sources of resting-state alpha rhythms were lower in amplitude in HIV subjects than in control subjects. Conclusions: The present results suggest that topography and frequency of the cortical sources of resting-state EEG rhythms can distinguish groups of HIV and control subjects. Significance: These results encourage future studies in an enlarged cohort of HIV subjects to test the hypothesis that the present methodological approach provides clinically useful information for an early detection of the effect of HIV infection on brain and cognitive functions.
KW - Alpha
KW - Brain rhythms
KW - Cognitive decline
KW - Human immunodeficiency virus (HIV)
KW - Low-resolution brain electromagnetic source tomography (LORETA)
KW - Resting-state electroencephalography (EEG)
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U2 - 10.1016/j.clinph.2012.06.002
DO - 10.1016/j.clinph.2012.06.002
M3 - Article
C2 - 22898369
AN - SCOPUS:84866995912
VL - 123
SP - 2163
EP - 2171
JO - Clinical Neurophysiology
JF - Clinical Neurophysiology
SN - 1388-2457
IS - 11
ER -