Cortical sources of resting state EEG rhythms are related to brain hypometabolism in subjects with Alzheimer's disease: an EEG-PET study

Claudio Babiloni, Claudio Del Percio, Anna Caroli, Elena Salvatore, Emanuele Nicolai, Nicola Marzano, Roberta Lizio, Enrica Cavedo, Susan Landau, Kewei Chen, William Jagust, Eric Reiman, Gioacchino Tedeschi, Patrizia Montella, Manuela De Stefano, Loreto Gesualdo, Giovanni B. Frisoni, Andrea Soricelli

Research output: Contribution to journalArticle

Abstract

Cortical sources of resting state electroencephalographic (EEG) delta (2–4 Hz) and low-frequency alpha (8–10.5 Hz) rhythms show abnormal activity (i.e., current density) in patients with dementia due to Alzheimer's disease (AD). Here, we hypothesized that abnormality of this activity is related to relevant disease processes as revealed by cortical hypometabolism typically observed in AD patients by fluorodeoxyglucose positron emission tomography. Resting state eyes-closed EEG data were recorded in 19 AD patients with dementia and 40 healthy elderly (Nold) subjects. EEG frequency bands of interest were delta and low-frequency alpha. EEG sources were estimated in these bands by low-resolution brain electromagnetic tomography (LORETA). Fluorodeoxyglucose positron emission tomography images were recorded only in the AD patients, and cortical hypometabolism was indexed by the so-called Alzheimer's discrimination analysis tool (PALZ) in the frontal association, ventromedial frontal, temporoparietal association, posterior cingulate, and precuneus areas. Results showed that compared with the Nold group, the AD group pointed to higher activity of delta sources and lower activity of low-frequency alpha sources in a cortical region of interest formed by all cortical areas of the PALZ score. In the AD patients, there was a positive correlation between the PALZ score and the activity of delta sources in the cortical region of interest (p < 0.05). These results suggest a relationship between resting state cortical hypometabolism and synchronization of cortical neurons at delta rhythms in AD patients with dementia.

Original languageEnglish
Pages (from-to)122-134
Number of pages13
JournalNeurobiology of Aging
Volume48
DOIs
Publication statusPublished - Dec 1 2016

Keywords

  • Alzheimer's disease (AD)
  • Brain hypometabolism
  • Electroencephalography (EEG)
  • Fluorodeoxyglucose positron emission tomography (FDG-PET)
  • Low resolution brain electromagnetic tomography (LORETA)

ASJC Scopus subject areas

  • Neuroscience(all)
  • Ageing
  • Developmental Biology
  • Geriatrics and Gerontology
  • Clinical Neurology

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    Babiloni, C., Del Percio, C., Caroli, A., Salvatore, E., Nicolai, E., Marzano, N., Lizio, R., Cavedo, E., Landau, S., Chen, K., Jagust, W., Reiman, E., Tedeschi, G., Montella, P., De Stefano, M., Gesualdo, L., Frisoni, G. B., & Soricelli, A. (2016). Cortical sources of resting state EEG rhythms are related to brain hypometabolism in subjects with Alzheimer's disease: an EEG-PET study. Neurobiology of Aging, 48, 122-134. https://doi.org/10.1016/j.neurobiolaging.2016.08.021