Cortical sources of resting-state EEG rhythms in "experienced" HIV subjects under antiretroviral therapy

Claudio Babiloni, Paola Buffo, Fabrizio Vecchio, Paolo Onorati, Chiara Muratori, Stefano Ferracuti, Paolo Roma, Michele Battuello, Nicole Donato, Giuseppe Noce, Francesco Di Campli, Laura Gianserra, Elisabetta Teti, Antonio Aceti, Andrea Soricelli, Magdalena Viscione, Massimo Andreoni, Paolo M. Rossini, Alfredo Pennica

Research output: Contribution to journalArticlepeer-review


Objective: Treatment-naïve patients with human immunodeficiency virus (HIV) are characterized by diffuse abnormalities of resting-state cortical electroencephalographic (EEG) rhythms (Babiloni et al., 2012a). Here, we tested the hypothesis that these EEG rhythms vary as a function of the systemic immune activity and antiretroviral therapy (ART) in HIV patients. Methods: Resting-state eyes-closed EEG data were recorded in 68 ART-HIV patients (mini mental state evaluation (MMSE) of 27.5. ±. 0.3 SEM), in 60 treatment-naïve HIV subjects (MMSE of 27.5. ±. 0.4 SEM) and in 75 age-matched cognitively normal subjects (MMSE of 29.3. ±. 0.1 SEM). Based on the CD4 lymphocytes' count, we divided ART-HIV subjects into two subgroups: those with CD4. >. 500. cells/μl (ART-HIV+) and those with CD4.

Original languageEnglish
Pages (from-to)1792-1802
Number of pages11
JournalClinical Neurophysiology
Issue number9
Publication statusPublished - 2014


  • Alpha
  • Brain rhythms
  • CD4 lymphocyte
  • Human immunodeficiency virus (HIV)
  • Low-resolution brain electromagnetic source tomography (LORETA)
  • Resting-state electroencephalography (EEG)

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Physiology (medical)
  • Sensory Systems
  • Medicine(all)


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