TY - JOUR
T1 - Cortical sources of resting state electroencephalographic rhythms probe brain function in naïve HIV individuals
AU - Babiloni, Claudio
AU - Noce, Giuseppe
AU - Pennica, Alfredo
AU - Onorati, Paolo
AU - Capotosto, Paolo
AU - Del Percio, Claudio
AU - Roma, Paolo
AU - Correr, Valentina
AU - Piccinni, Elisa
AU - Toma, Ginevra
AU - Soricelli, Andrea
AU - Di Campli, Francesco
AU - Gianserra, Laura
AU - Ciullini, Lorenzo
AU - Aceti, Antonio
AU - Teti, Elisabetta
AU - Sarmati, Loredana
AU - Crocetti, Gloria
AU - Ferri, Raffaele
AU - Catania, Valentina
AU - Pascarelli, Maria Teresa
AU - Andreoni, Massimo
AU - Ferracuti, Stefano
PY - 2018/2/1
Y1 - 2018/2/1
N2 - Objective Here we evaluated the hypothesis that resting state electroencephalographic (EEG) cortical sources correlated with cognitive functions and discriminated asymptomatic treatment-naïve HIV subjects (no AIDS). Methods EEG, clinical, and neuropsychological data were collected in 103 treatment-naïve HIV subjects (88 males; mean age 39.8 years ± 1.1 standard error of the mean, SE). An age-matched group of 70 cognitively normal and HIV-negative (Healthy; 56 males; 39.0 years ± 2.0 SE) subjects, selected from a local university archive, was used for control purposes. LORETA freeware was used for EEG source estimation in fronto-central, temporal, and parieto-occipital regions of interest. Results Widespread sources of delta (<4 Hz) and alpha (8–12 Hz) rhythms were abnormal in the treatment-naïve HIV group. Fronto-central delta source activity showed a slight but significant (p < 0.05, corrected) negative correlation with verbal and semantic test scores. So did parieto-occipital delta/alpha source ratio with memory and composite cognitive scores. These sources allowed a moderate classification accuracy between HIV and control individuals (area under the ROC curves of 70–75%). Conclusions Regional EEG abnormalities in quiet wakefulness characterized treatment-naïve HIV subjects at the individual level. Significance This EEG approach may contribute to the management of treatment-naïve HIV subjects at risk of cognitive deficits.
AB - Objective Here we evaluated the hypothesis that resting state electroencephalographic (EEG) cortical sources correlated with cognitive functions and discriminated asymptomatic treatment-naïve HIV subjects (no AIDS). Methods EEG, clinical, and neuropsychological data were collected in 103 treatment-naïve HIV subjects (88 males; mean age 39.8 years ± 1.1 standard error of the mean, SE). An age-matched group of 70 cognitively normal and HIV-negative (Healthy; 56 males; 39.0 years ± 2.0 SE) subjects, selected from a local university archive, was used for control purposes. LORETA freeware was used for EEG source estimation in fronto-central, temporal, and parieto-occipital regions of interest. Results Widespread sources of delta (<4 Hz) and alpha (8–12 Hz) rhythms were abnormal in the treatment-naïve HIV group. Fronto-central delta source activity showed a slight but significant (p < 0.05, corrected) negative correlation with verbal and semantic test scores. So did parieto-occipital delta/alpha source ratio with memory and composite cognitive scores. These sources allowed a moderate classification accuracy between HIV and control individuals (area under the ROC curves of 70–75%). Conclusions Regional EEG abnormalities in quiet wakefulness characterized treatment-naïve HIV subjects at the individual level. Significance This EEG approach may contribute to the management of treatment-naïve HIV subjects at risk of cognitive deficits.
KW - Human immunodeficiency virus (HIV)
KW - Low-resolution brain electromagnetic source tomography (LORETA)
KW - Neuropsychological assessment
KW - Resting-state electroencephalography (EEG)
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U2 - 10.1016/j.clinph.2017.12.002
DO - 10.1016/j.clinph.2017.12.002
M3 - Article
AN - SCOPUS:85039854269
VL - 129
SP - 431
EP - 441
JO - Clinical Neurophysiology
JF - Clinical Neurophysiology
SN - 1388-2457
IS - 2
ER -