Cortical white-matter microstructure in schizophrenia: Diffusion imaging study

N. Andreone, M. Tansella, R. Cerini, A. Versace, G. Rambaldelli, C. Perlini, N. Dusi, L. Pelizza, M. Balestrieri, C. Barbui, M. Nosè, A. Gasparini, Paolo Brambilla

Research output: Contribution to journalArticlepeer-review


Background: Several, although not all, of the previous small diffusion-weighted imaging (DWI) studies have shown cortical white-matter disruption in schizophrenia. Aims: To investigate cortical white-matter microstructure with DWI in a large community-based sample of people with schizophrenia. Method: Sixty-eight people with schizophrenia and 64 healthy controls underwent a session of DWI to obtain the apparent diffusion coefficient (ADC) of white-matter water molecules. Regions of interest were placed in cortical lobes. Results: Compared with controls, the schizophrenia group had significantly greater ADCs in frontal, temporal and occipital white matter (analysis of covariance, P <0.05). Conclusions: Our findings confirm the presence of cortical white-matter microstructure disruption in frontal and temporo-occipital lobes in the largest sample of people with schizophrenia thus for studied with this technique. Future brain imaging studies, together with genetic investigations, should further explore white-matter integrity and genes encoding myelin-related protein expression in people with first-episode schizophrenia and those at high risk of developing the disorder.

Original languageEnglish
Pages (from-to)113-119
Number of pages7
JournalBritish Journal of Psychiatry
Issue numberAUG.
Publication statusPublished - Aug 2007

ASJC Scopus subject areas

  • Neuroscience(all)
  • Psychiatry and Mental health


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