TY - JOUR
T1 - Cortical white-matter microstructure in schizophrenia
T2 - Diffusion imaging study
AU - Andreone, N.
AU - Tansella, M.
AU - Cerini, R.
AU - Versace, A.
AU - Rambaldelli, G.
AU - Perlini, C.
AU - Dusi, N.
AU - Pelizza, L.
AU - Balestrieri, M.
AU - Barbui, C.
AU - Nosè, M.
AU - Gasparini, A.
AU - Brambilla, Paolo
PY - 2007/8
Y1 - 2007/8
N2 - Background: Several, although not all, of the previous small diffusion-weighted imaging (DWI) studies have shown cortical white-matter disruption in schizophrenia. Aims: To investigate cortical white-matter microstructure with DWI in a large community-based sample of people with schizophrenia. Method: Sixty-eight people with schizophrenia and 64 healthy controls underwent a session of DWI to obtain the apparent diffusion coefficient (ADC) of white-matter water molecules. Regions of interest were placed in cortical lobes. Results: Compared with controls, the schizophrenia group had significantly greater ADCs in frontal, temporal and occipital white matter (analysis of covariance, P <0.05). Conclusions: Our findings confirm the presence of cortical white-matter microstructure disruption in frontal and temporo-occipital lobes in the largest sample of people with schizophrenia thus for studied with this technique. Future brain imaging studies, together with genetic investigations, should further explore white-matter integrity and genes encoding myelin-related protein expression in people with first-episode schizophrenia and those at high risk of developing the disorder.
AB - Background: Several, although not all, of the previous small diffusion-weighted imaging (DWI) studies have shown cortical white-matter disruption in schizophrenia. Aims: To investigate cortical white-matter microstructure with DWI in a large community-based sample of people with schizophrenia. Method: Sixty-eight people with schizophrenia and 64 healthy controls underwent a session of DWI to obtain the apparent diffusion coefficient (ADC) of white-matter water molecules. Regions of interest were placed in cortical lobes. Results: Compared with controls, the schizophrenia group had significantly greater ADCs in frontal, temporal and occipital white matter (analysis of covariance, P <0.05). Conclusions: Our findings confirm the presence of cortical white-matter microstructure disruption in frontal and temporo-occipital lobes in the largest sample of people with schizophrenia thus for studied with this technique. Future brain imaging studies, together with genetic investigations, should further explore white-matter integrity and genes encoding myelin-related protein expression in people with first-episode schizophrenia and those at high risk of developing the disorder.
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U2 - 10.1192/bjp.bp.105.020990
DO - 10.1192/bjp.bp.105.020990
M3 - Article
C2 - 17666494
AN - SCOPUS:34547638435
VL - 191
SP - 113
EP - 119
JO - British Journal of Psychiatry
JF - British Journal of Psychiatry
SN - 0007-1250
IS - AUG.
ER -