Cortico-subcortical metabolic correlates of olfactory processing in healthy resting subjects

Marco Alessandrini, Alessandro Micarelli, Agostino Chiaravalloti, Matteo Candidi, Ernesto Bruno, Barbara Di Pietro, Orazio Schillaci, Marco Pagani

Research output: Contribution to journalArticlepeer-review


A wide network of interconnected areas was previously found in neuroimaging studies involving normal as well as pathological subjects; however literature seems to suffer from a lack of investigation in glucose metabolism behaviour under olfactory condition. Thus, the present work describe for the first time a pure olfactory related brain response of metabolism by using 18F-fluorodeoxyglucose-Positron Emission Tomography/Computer Tomography in eleven resting subjects undergoing a neutral and a pure olfactory condition. By contrasting these experimental phases, it was possible to depict a re-organization pattern of default mode network structures in a relatively ecological environment. Moreover, by correlating such pattern with a battery of validated olfactory and neuropsychological tests, our work allowed in showing peculiar correlation data that could cluster the subjects sample in a certain range of normality. We believe the present study could integrate the current knowledge in olfactory research and could be a start-up for future contributions.

Original languageEnglish
Article number5146
JournalScientific Reports
Publication statusPublished - Jun 3 2014

ASJC Scopus subject areas

  • General
  • Medicine(all)


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