Corticobasal degeneration: Neuropsychological assessment and dopamine D2 receptor spect analysis

Giovanni B. Frisoni, Gilberto Pizzolato, Orazio Zanetti, Angelo Bianchetti, Franca Chierichetti, Marco Trabucchi

Research output: Contribution to journalArticlepeer-review

Abstract

We report a case of clinically diagnosed corticobasal degeneration, in whom neuropsychological testing was performed along with functional imaging with IBZM SPECT. HM-PAO SPECT showed marked perfusion asymmetry in parielal cortical regions, lower to the right, contralateral to the most affected side. IB7.M SPF.CT. which gives information about postsynaptic dopaminergic Di receptors, showed severe reduction of tracer uptake in the right basal ganglia. Our findings suggesi that a postsynaptic lesion in the basal ganglia might account for the lack of response of extrapyramidal motor symptoms to dopaminergic agonists in corticobasal degeneration.

Original languageEnglish
Pages (from-to)50-54
Number of pages5
JournalEuropean Neurology
Volume35
Issue number1
DOIs
Publication statusPublished - 1995

Keywords

  • Corticobasal degeneration
  • D<inf>2</inf>receptors
  • Dopamine
  • Neuropsychology
  • SPECT

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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