Corticolimbic connectivity as a possible biomarker for bipolar disorder

Benedetta Vai, Irene Bollettini, Francesco Benedetti

Research output: Contribution to journalArticlepeer-review


Bipolar disorder is a severe, disabling and life-threatening illness, which affects nearly 2% of the general population. The identification of reliable and objective biomarkers may aid early diagnosis and optimize treatment efficacy. Through a careful overview of the neuroimaging studies which investigated the structural, functional, and effective connectivity in bipolar disorder, we explored the role of a disconnected cortico-limbic circuitry in the development and maintenance of the disorder. This review offers perspectives and suggestions for future research, in order to propose the corticolimbic disconnection as a neurobiological underpinning and biomarker for bipolar psychopathology.

Original languageEnglish
Pages (from-to)631-650
Number of pages20
JournalExpert Review of Neurotherapeutics
Issue number6
Publication statusPublished - 2014


  • biomarker
  • bipolar disorder
  • connectivity
  • corticolimbic circuitry
  • development

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Pharmacology (medical)
  • Medicine(all)


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