Corticospinal Excitability during motor imagery of a simple tonic finger movement in patients with writer's cramp

Angelo Quartarone, Sergio Bagnato, Vincenzo Rizzo, Francesca Morgante, Antonino Sant'Angelo, Domenica Crupi, Marcello Romano, Corrado Messina, Alfredo Berardelli, Paolo Girlanda

Research output: Contribution to journalArticle

Abstract

Motor imagery (MI) is the mental rehearsal of a motor act without overt movement. Using transcranial magnetic stimulation (TMS), we tested the effect of MI on corticospinal excitability in patients with writer's cramp. In 10 patients with writer's cramp and 10 healthy controls, we applied focal TMS over each primary motor area and recorded motor evoked potentials (MEPs) from contralateral hand and arm muscles while participants imagined a tonic abduction of the index finger contralateral to the stimulated hemisphere. In healthy controls and patients, the MEP amplitude in the relaxed first dorsal interosseus muscle (FDI) showed a muscle-specific increase during MI; however, the increase was less pronounced in patients than in healthy controls. In addition, in patients but not in controls, the MEP amplitude also increased in hand and forearm muscles not involved in the imagined movement. This abnormal spread of facilitation was observed in the affected and unaffected upper limb. MI of simple hand movements is less efficient and less focussed in patients with writer's cramp than it is in normal subjects.

Original languageEnglish
Pages (from-to)1488-1495
Number of pages8
JournalMovement Disorders
Volume20
Issue number11
DOIs
Publication statusPublished - Nov 2005

Keywords

  • Dystonia
  • Motor imagery
  • Transcranial magnetic stimulation (TMS)
  • Writer's cramp

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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    Quartarone, A., Bagnato, S., Rizzo, V., Morgante, F., Sant'Angelo, A., Crupi, D., Romano, M., Messina, C., Berardelli, A., & Girlanda, P. (2005). Corticospinal Excitability during motor imagery of a simple tonic finger movement in patients with writer's cramp. Movement Disorders, 20(11), 1488-1495. https://doi.org/10.1002/mds.20626