Abstract
Background: Prader-Willi syndrome (PWS) is a genetic developmental disorder, mostly caused by a deletion on the paternal chromosome 15 or by a maternal uniparental disomy 15. Some PWS clinical and neurochemical features suggest an involvement of the corticospinal motor structures. Objective: To explore the corticospinal physiology of PWS by transcranial magnetic stimulation. Setting: A community-based hospital. Methods: We studied motor evoked potentials in the first dorsal interosseous muscle of 21 young-adult patients with PWS. Thirteen patients had a deletion at chromosome 15; 8 had a uniparental disomy. We measured the following variables: relaxed motor threshold, central motor conduction time, duration of the central silent period, and short-interval intracortical inhibition and facilitation. We also recorded F waves in the first dorsal interosseous muscle. We had 11 normal controls. Results: In the whole PWS group, motor threshold was higher as compared with controls (P
| Original language | English |
|---|---|
| Pages (from-to) | 1585-1589 |
| Number of pages | 5 |
| Journal | Archives of Neurology |
| Volume | 61 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - Oct 2004 |
Fingerprint
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Corticospinal physiology in patients with prader-willi syndrome : A transcranial magnetic stimulation study. / Civardi, Carlo; Vicentini, Roberta; Grugni, Graziano; Cantello, Roberto.
In: Archives of Neurology, Vol. 61, No. 10, 10.2004, p. 1585-1589.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Corticospinal physiology in patients with prader-willi syndrome
T2 - A transcranial magnetic stimulation study
AU - Civardi, Carlo
AU - Vicentini, Roberta
AU - Grugni, Graziano
AU - Cantello, Roberto
PY - 2004/10
Y1 - 2004/10
N2 - Background: Prader-Willi syndrome (PWS) is a genetic developmental disorder, mostly caused by a deletion on the paternal chromosome 15 or by a maternal uniparental disomy 15. Some PWS clinical and neurochemical features suggest an involvement of the corticospinal motor structures. Objective: To explore the corticospinal physiology of PWS by transcranial magnetic stimulation. Setting: A community-based hospital. Methods: We studied motor evoked potentials in the first dorsal interosseous muscle of 21 young-adult patients with PWS. Thirteen patients had a deletion at chromosome 15; 8 had a uniparental disomy. We measured the following variables: relaxed motor threshold, central motor conduction time, duration of the central silent period, and short-interval intracortical inhibition and facilitation. We also recorded F waves in the first dorsal interosseous muscle. We had 11 normal controls. Results: In the whole PWS group, motor threshold was higher as compared with controls (P
AB - Background: Prader-Willi syndrome (PWS) is a genetic developmental disorder, mostly caused by a deletion on the paternal chromosome 15 or by a maternal uniparental disomy 15. Some PWS clinical and neurochemical features suggest an involvement of the corticospinal motor structures. Objective: To explore the corticospinal physiology of PWS by transcranial magnetic stimulation. Setting: A community-based hospital. Methods: We studied motor evoked potentials in the first dorsal interosseous muscle of 21 young-adult patients with PWS. Thirteen patients had a deletion at chromosome 15; 8 had a uniparental disomy. We measured the following variables: relaxed motor threshold, central motor conduction time, duration of the central silent period, and short-interval intracortical inhibition and facilitation. We also recorded F waves in the first dorsal interosseous muscle. We had 11 normal controls. Results: In the whole PWS group, motor threshold was higher as compared with controls (P
UR - http://www.scopus.com/inward/record.url?scp=5344256214&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=5344256214&partnerID=8YFLogxK
U2 - 10.1001/archneur.61.10.1585
DO - 10.1001/archneur.61.10.1585
M3 - Article
C2 - 15477513
AN - SCOPUS:5344256214
VL - 61
SP - 1585
EP - 1589
JO - Archives of Neurology
JF - Archives of Neurology
SN - 0003-9942
IS - 10
ER -