Corticospinal physiology in patients with prader-willi syndrome: A transcranial magnetic stimulation study

Carlo Civardi, Roberta Vicentini, Graziano Grugni, Roberto Cantello

Research output: Contribution to journalArticle

Abstract

Background: Prader-Willi syndrome (PWS) is a genetic developmental disorder, mostly caused by a deletion on the paternal chromosome 15 or by a maternal uniparental disomy 15. Some PWS clinical and neurochemical features suggest an involvement of the corticospinal motor structures. Objective: To explore the corticospinal physiology of PWS by transcranial magnetic stimulation. Setting: A community-based hospital. Methods: We studied motor evoked potentials in the first dorsal interosseous muscle of 21 young-adult patients with PWS. Thirteen patients had a deletion at chromosome 15; 8 had a uniparental disomy. We measured the following variables: relaxed motor threshold, central motor conduction time, duration of the central silent period, and short-interval intracortical inhibition and facilitation. We also recorded F waves in the first dorsal interosseous muscle. We had 11 normal controls. Results: In the whole PWS group, motor threshold was higher as compared with controls (P

Original languageEnglish
Pages (from-to)1585-1589
Number of pages5
JournalArchives of Neurology
Volume61
Issue number10
DOIs
Publication statusPublished - Oct 2004

Fingerprint

Prader-Willi Syndrome
Transcranial Magnetic Stimulation
Chromosomes, Human, Pair 15
Uniparental Disomy
Motor Evoked Potentials
Muscles
Chromosomes, Human, Pair 8
Inborn Genetic Diseases
Community Hospital
Young Adult
Mothers
Physiology
Syndrome

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Corticospinal physiology in patients with prader-willi syndrome : A transcranial magnetic stimulation study. / Civardi, Carlo; Vicentini, Roberta; Grugni, Graziano; Cantello, Roberto.

In: Archives of Neurology, Vol. 61, No. 10, 10.2004, p. 1585-1589.

Research output: Contribution to journalArticle

Civardi, Carlo ; Vicentini, Roberta ; Grugni, Graziano ; Cantello, Roberto. / Corticospinal physiology in patients with prader-willi syndrome : A transcranial magnetic stimulation study. In: Archives of Neurology. 2004 ; Vol. 61, No. 10. pp. 1585-1589.
@article{fe05435068be44ecac4c7c61a66a0961,
title = "Corticospinal physiology in patients with prader-willi syndrome: A transcranial magnetic stimulation study",
abstract = "Background: Prader-Willi syndrome (PWS) is a genetic developmental disorder, mostly caused by a deletion on the paternal chromosome 15 or by a maternal uniparental disomy 15. Some PWS clinical and neurochemical features suggest an involvement of the corticospinal motor structures. Objective: To explore the corticospinal physiology of PWS by transcranial magnetic stimulation. Setting: A community-based hospital. Methods: We studied motor evoked potentials in the first dorsal interosseous muscle of 21 young-adult patients with PWS. Thirteen patients had a deletion at chromosome 15; 8 had a uniparental disomy. We measured the following variables: relaxed motor threshold, central motor conduction time, duration of the central silent period, and short-interval intracortical inhibition and facilitation. We also recorded F waves in the first dorsal interosseous muscle. We had 11 normal controls. Results: In the whole PWS group, motor threshold was higher as compared with controls (P",
author = "Carlo Civardi and Roberta Vicentini and Graziano Grugni and Roberto Cantello",
year = "2004",
month = "10",
doi = "10.1001/archneur.61.10.1585",
language = "English",
volume = "61",
pages = "1585--1589",
journal = "Archives of Neurology",
issn = "0003-9942",
publisher = "American Medical Association",
number = "10",

}

TY - JOUR

T1 - Corticospinal physiology in patients with prader-willi syndrome

T2 - A transcranial magnetic stimulation study

AU - Civardi, Carlo

AU - Vicentini, Roberta

AU - Grugni, Graziano

AU - Cantello, Roberto

PY - 2004/10

Y1 - 2004/10

N2 - Background: Prader-Willi syndrome (PWS) is a genetic developmental disorder, mostly caused by a deletion on the paternal chromosome 15 or by a maternal uniparental disomy 15. Some PWS clinical and neurochemical features suggest an involvement of the corticospinal motor structures. Objective: To explore the corticospinal physiology of PWS by transcranial magnetic stimulation. Setting: A community-based hospital. Methods: We studied motor evoked potentials in the first dorsal interosseous muscle of 21 young-adult patients with PWS. Thirteen patients had a deletion at chromosome 15; 8 had a uniparental disomy. We measured the following variables: relaxed motor threshold, central motor conduction time, duration of the central silent period, and short-interval intracortical inhibition and facilitation. We also recorded F waves in the first dorsal interosseous muscle. We had 11 normal controls. Results: In the whole PWS group, motor threshold was higher as compared with controls (P

AB - Background: Prader-Willi syndrome (PWS) is a genetic developmental disorder, mostly caused by a deletion on the paternal chromosome 15 or by a maternal uniparental disomy 15. Some PWS clinical and neurochemical features suggest an involvement of the corticospinal motor structures. Objective: To explore the corticospinal physiology of PWS by transcranial magnetic stimulation. Setting: A community-based hospital. Methods: We studied motor evoked potentials in the first dorsal interosseous muscle of 21 young-adult patients with PWS. Thirteen patients had a deletion at chromosome 15; 8 had a uniparental disomy. We measured the following variables: relaxed motor threshold, central motor conduction time, duration of the central silent period, and short-interval intracortical inhibition and facilitation. We also recorded F waves in the first dorsal interosseous muscle. We had 11 normal controls. Results: In the whole PWS group, motor threshold was higher as compared with controls (P

UR - http://www.scopus.com/inward/record.url?scp=5344256214&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=5344256214&partnerID=8YFLogxK

U2 - 10.1001/archneur.61.10.1585

DO - 10.1001/archneur.61.10.1585

M3 - Article

C2 - 15477513

AN - SCOPUS:5344256214

VL - 61

SP - 1585

EP - 1589

JO - Archives of Neurology

JF - Archives of Neurology

SN - 0003-9942

IS - 10

ER -