TY - JOUR
T1 - Corticospinal physiology in patients with prader-willi syndrome
T2 - A transcranial magnetic stimulation study
AU - Civardi, Carlo
AU - Vicentini, Roberta
AU - Grugni, Graziano
AU - Cantello, Roberto
PY - 2004/10
Y1 - 2004/10
N2 - Background: Prader-Willi syndrome (PWS) is a genetic developmental disorder, mostly caused by a deletion on the paternal chromosome 15 or by a maternal uniparental disomy 15. Some PWS clinical and neurochemical features suggest an involvement of the corticospinal motor structures. Objective: To explore the corticospinal physiology of PWS by transcranial magnetic stimulation. Setting: A community-based hospital. Methods: We studied motor evoked potentials in the first dorsal interosseous muscle of 21 young-adult patients with PWS. Thirteen patients had a deletion at chromosome 15; 8 had a uniparental disomy. We measured the following variables: relaxed motor threshold, central motor conduction time, duration of the central silent period, and short-interval intracortical inhibition and facilitation. We also recorded F waves in the first dorsal interosseous muscle. We had 11 normal controls. Results: In the whole PWS group, motor threshold was higher as compared with controls (P
AB - Background: Prader-Willi syndrome (PWS) is a genetic developmental disorder, mostly caused by a deletion on the paternal chromosome 15 or by a maternal uniparental disomy 15. Some PWS clinical and neurochemical features suggest an involvement of the corticospinal motor structures. Objective: To explore the corticospinal physiology of PWS by transcranial magnetic stimulation. Setting: A community-based hospital. Methods: We studied motor evoked potentials in the first dorsal interosseous muscle of 21 young-adult patients with PWS. Thirteen patients had a deletion at chromosome 15; 8 had a uniparental disomy. We measured the following variables: relaxed motor threshold, central motor conduction time, duration of the central silent period, and short-interval intracortical inhibition and facilitation. We also recorded F waves in the first dorsal interosseous muscle. We had 11 normal controls. Results: In the whole PWS group, motor threshold was higher as compared with controls (P
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U2 - 10.1001/archneur.61.10.1585
DO - 10.1001/archneur.61.10.1585
M3 - Article
C2 - 15477513
AN - SCOPUS:5344256214
VL - 61
SP - 1585
EP - 1589
JO - Archives of Neurology
JF - Archives of Neurology
SN - 0003-9942
IS - 10
ER -