Attività immunologica dei corticosteroidi

Translated title of the contribution: Corticosteroids activity at the immunologic level

Marco Scudeletti, Cristina Musselli, Lorella Lanza, Lorenza Peirano, Francesco Puppo, Francesco Indiveri

Research output: Contribution to journalArticle

Abstract

Corticosteroids are among the most used anti-inflammatory and immunosuppressive drugs. The most recent reports have shown that the corticosteroids: A) modulate the lymphocyte recirculation and induce a lymphocyte depletion mainly regarding to the CD4 cells. B) Inhibit several lymphocyte activities, as well as their capacity to secrete cytokines and their clonal expansion under activating conditions. C) Induce apoptosis in primed T cells. D) Modulate the synthesis and activity of nuclear factors AP1 and NFkB. Moreover several data suggest that the molecular manipulations of cortisol, performed with the aim of improving its therapeutic efficiency, might change its capacity to bind the cytoplasmic receptor and/or generate CTS/CTS-R compounds that have different capacity to migrate through the nuclear membrane and/or to activate the nuclear responsive elements inducing different biologic responses.

Translated title of the contributionCorticosteroids activity at the immunologic level
Original languageItalian
Pages (from-to)508-515
Number of pages8
JournalRecenti Progressi in Medicina
Volume87
Issue number10
Publication statusPublished - Oct 1996

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Scudeletti, M., Musselli, C., Lanza, L., Peirano, L., Puppo, F., & Indiveri, F. (1996). Attività immunologica dei corticosteroidi. Recenti Progressi in Medicina, 87(10), 508-515.