Corticosteroids protect oligodendrocytes from cytokine-induced cell death

Roberto C. Melcangi, Ilaria Cavarretta, Valerio Magnaghi, Emilio Ciusani, Andrea Salmaggi

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

The present data show that the simultaneous exposure to tumor necrosis factor-α (TNFα) and interferon-γ (IFNγ) induces cell death with characteristics of apoptosis in cultured rat oligodendrocytes; TNFα alone was ineffective. We have also demonstrated that different corticosteroids (aldosterone, deoxycorticosterone, dexamethasone and corticosterone) protect rat oligodendrocytes in culture from apoptosis induced by TNFα plus IFNγ. This effect seems to be exerted via the interaction with both type I and type II corticosteroid receptors since all steroids considered are effective. Since oligodendrocyte apoptosis represents an important event in multiple sclerosis and in several demyelinating diseases, the present observations might be considered an interesting background for further researches directed to the possibility of controlling in vivo the death of these cells.

Original languageEnglish
Pages (from-to)3969-3972
Number of pages4
JournalNeuroReport
Volume11
Issue number18
Publication statusPublished - 2000

Fingerprint

Oligodendroglia
Adrenal Cortex Hormones
Cell Death
Tumor Necrosis Factor-alpha
Apoptosis
Cytokines
Interferons
Desoxycorticosterone
Steroid Receptors
Demyelinating Diseases
Corticosterone
Aldosterone
Dexamethasone
Multiple Sclerosis
Steroids
Research

Keywords

  • Apoptosis
  • Corticosteroids
  • IFNγ
  • In vitro
  • Oligodendrocytes
  • Rat
  • TNFα

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Melcangi, R. C., Cavarretta, I., Magnaghi, V., Ciusani, E., & Salmaggi, A. (2000). Corticosteroids protect oligodendrocytes from cytokine-induced cell death. NeuroReport, 11(18), 3969-3972.

Corticosteroids protect oligodendrocytes from cytokine-induced cell death. / Melcangi, Roberto C.; Cavarretta, Ilaria; Magnaghi, Valerio; Ciusani, Emilio; Salmaggi, Andrea.

In: NeuroReport, Vol. 11, No. 18, 2000, p. 3969-3972.

Research output: Contribution to journalArticle

Melcangi, RC, Cavarretta, I, Magnaghi, V, Ciusani, E & Salmaggi, A 2000, 'Corticosteroids protect oligodendrocytes from cytokine-induced cell death', NeuroReport, vol. 11, no. 18, pp. 3969-3972.
Melcangi RC, Cavarretta I, Magnaghi V, Ciusani E, Salmaggi A. Corticosteroids protect oligodendrocytes from cytokine-induced cell death. NeuroReport. 2000;11(18):3969-3972.
Melcangi, Roberto C. ; Cavarretta, Ilaria ; Magnaghi, Valerio ; Ciusani, Emilio ; Salmaggi, Andrea. / Corticosteroids protect oligodendrocytes from cytokine-induced cell death. In: NeuroReport. 2000 ; Vol. 11, No. 18. pp. 3969-3972.
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