Corticostriatal plastic changes in experimental L-DOPA-induced dyskinesia

Veronica Ghiglieri, Vincenza Bagetta, Valentina Pendolino, Barbara Picconi, Paolo Calabresi

Research output: Contribution to journalArticlepeer-review

Abstract

In Parkinson's disease (PD), alteration of dopamine- (DA-) dependent striatal functions and pulsatile stimulation of DA receptors caused by the discontinuous administration of levodopa (L-DOPA) lead to a complex cascade of events affecting the postsynaptic striatal neurons that might account for the appearance of L-DOPA-induced dyskinesia (LID). Experimental models of LID have been widely used and extensively characterized in rodents and electrophysiological studies provided remarkable insights into the inner mechanisms underlying L-DOPA-induced corticostriatal plastic changes. Here we provide an overview of recent findings that represent a further step into the comprehension of mechanisms underlying maladaptive changes of basal ganglia functions in response to L-DOPA and associated to development of LID.

Original languageEnglish
Article number358176
JournalParkinson's Disease
DOIs
Publication statusPublished - 2012

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Clinical Neurology
  • Psychiatry and Mental health

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