Cost effectiveness analysis of disease-modifying antirheumatic drugs in rheumatoid arthritis. A systematic review literature

Maurizio Benucci, Gianantonio Saviola, Mariangela Manfredi, Piercarlo Sarzi-Puttini, Fabiola Atzeni

Research output: Contribution to journalArticle

Abstract

The cost effectiveness of treatments that have changed the "natural history" of a chronic progressive disease needs to be evaluated over the long term. Disease-modifying antirheumatic drugs (DMARDs) are the standard treatment of rheumatoid arthritis (RA) and should be started as early as possible. A number of studies have shown that they are effective in improving disease activity and function, and in joint damage. Our review was focused on revision and critical evaluation of the studies including the literature on cost effectiveness of DMARDs (cyclosporine A, sulphasalazine, leflunomide, and methotrexate). The European League Against Rheumatism (EULAR) recommendations showed that traditional DMARDs are cost effective at the time of disease onset. They are less expensive than biological DMARDs and can be useful in controlling disease activity in early RA.

Original languageEnglish
Article number845496
JournalInternational Journal of Rheumatology
Volume2011
DOIs
Publication statusPublished - 2011

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

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