TY - JOUR
T1 - Cost-effectiveness of enfuvirtide for treatment-experienced patients with HIV in Italy
AU - Hornberger, John
AU - Green, Jesse
AU - Wintfeld, Neil
AU - Cavassini, Matthias
AU - Rockstroh, Jürgen
AU - Giuliani, Giovanni
AU - De Carli, Claudio
AU - Lazzarin, Adriano
PY - 2005/3
Y1 - 2005/3
N2 - Background: Enfuvirtide (ENF) plus an optimized background (OB) antiretroviral regimen delays virological failure (VF), reduces HIV-1 viral load, and increases CD4 count compared with OB only in pretreated patients. Purpose: To forecast long-term outcomes, costs, and cost-effectiveness of ENF+OB vs. OB in the Italian health care system. Method: A Markov model was developed and clinical trial results on viral suppression and CD4 count were linked with data from HAART-era studies of the risk of AIDS-defining events (ADEs) and death. Resource data were obtained from Italian sources on direct medical costs. Cost-effectiveness was computed as the incremental cost per quality-adjusted life year (QALY) saved. Results: Patients receiving ENF+OB were projected to experience a mean time to virological failure of 1.0 years vs. 0.5 years for OB and mean time to immunological failure of 3.1 years vs. 1.3 years for OB. Life expectancy and QALYs were greater for ENF+OB than OB by 1.8 and 1.5 years, respectively. Total lifetime medical cost was €126,487 for ENF+OB and €84,416 for OB, a difference of €42,071 due to the cost of ENF itself (€18,400) and the medical costs associated with additional life expectancy (€23,671). The incremental cost-effectiveness of ENF+OB was €23,721 per life year (€28,669 per QALY). Conclusion: ENF+OB is predicted to increase life expectancy at a cost per life year that is comparable to many well-accepted therapies in Europe.
AB - Background: Enfuvirtide (ENF) plus an optimized background (OB) antiretroviral regimen delays virological failure (VF), reduces HIV-1 viral load, and increases CD4 count compared with OB only in pretreated patients. Purpose: To forecast long-term outcomes, costs, and cost-effectiveness of ENF+OB vs. OB in the Italian health care system. Method: A Markov model was developed and clinical trial results on viral suppression and CD4 count were linked with data from HAART-era studies of the risk of AIDS-defining events (ADEs) and death. Resource data were obtained from Italian sources on direct medical costs. Cost-effectiveness was computed as the incremental cost per quality-adjusted life year (QALY) saved. Results: Patients receiving ENF+OB were projected to experience a mean time to virological failure of 1.0 years vs. 0.5 years for OB and mean time to immunological failure of 3.1 years vs. 1.3 years for OB. Life expectancy and QALYs were greater for ENF+OB than OB by 1.8 and 1.5 years, respectively. Total lifetime medical cost was €126,487 for ENF+OB and €84,416 for OB, a difference of €42,071 due to the cost of ENF itself (€18,400) and the medical costs associated with additional life expectancy (€23,671). The incremental cost-effectiveness of ENF+OB was €23,721 per life year (€28,669 per QALY). Conclusion: ENF+OB is predicted to increase life expectancy at a cost per life year that is comparable to many well-accepted therapies in Europe.
KW - Cost-benefit analysis
KW - Enfuvirtide
KW - HIV
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U2 - 10.1310/REJM-TAFW-0A7T-97UA
DO - 10.1310/REJM-TAFW-0A7T-97UA
M3 - Article
C2 - 15983893
AN - SCOPUS:25144449133
VL - 6
SP - 92
EP - 102
JO - HIV Clinical Trials
JF - HIV Clinical Trials
SN - 1528-4336
IS - 2
ER -