Cost-effectiveness of preimplantation genetic testing for aneuploidies

Edgardo Somigliana, Andrea Busnelli, Alessio Paffoni, Paola Vigano, Alessandra Riccaboni, Carmen Rubio, Antonio Capalbo

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To evaluate the economical benefit of preimplantation genetic testing of aneuploidies (PGT-A) when applied in an extended culture and stringent elective single ET framework. Design: Theoretical cost-effectiveness study. Setting: Not applicable. Patients/Animal(s): None. Intervention(s): Comparison of the cost-effectiveness between two IVF treatment strategies: serial transfer of all available blastocysts without genetic testing (first fresh transfer and subsequent frozen-thawed transfer); and systematic use of genetic testing (trophectoderm biopsy, freeze-all, and frozen-thawed transfers of euploid blastocysts). The costs considered for this analysis are based on regional public health system provider. Main Outcome Measure(s): Costs per live birth. Result(s): Cost-effectiveness profile of PGT-A improves with female age and number of available blastocysts. Sensitivity analyses varying the costs of ET, the costs of genetic analyses, the magnitude of the detrimental impact of PGT-A on live birth rate, and the crude live birth rates change to some extent the thresholds for effectiveness but generally confirm the notion that PGT-A can be economically advantageous in some specific subgroups. Conclusion(s): PGT-A can be cost-effective in specific clinical settings and population groups. Economic considerations deserve attention in the debate regarding the clinical utility of PGT-A.

Original languageEnglish
Pages (from-to)1169-1176
JournalFertility and Sterility
Volume111
Issue number6
DOIs
Publication statusPublished - Jan 1 2019

Keywords

  • blastocyst
  • effectiveness
  • elective single embryo transfer
  • Preimplantation genetic testing

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

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