Cost-minimisation analysis comparing gemcitabine/cisplatin, paclitaxel/carboplatin and vinorelbine/cisplatin in the treatment of advanced non-small cell lung cancer in Italy

S. Novello, A. Kielhorn, G. Stynes, G. Selvaggi, F. De Marinis, A. Maestri, P. Foggi, D. Tilden, M. Tonato, L. Crinò, M. Rinaldi, A. M. Migliorino, G. V. Scagliotti

Research output: Contribution to journalArticle

Abstract

A retrospective cost-minimisation analysis was conducted comparing novel chemotherapies for the treatment of chemo-naive patients with locally advanced, recurrent, and/or metastatic non-small cell lung cancer (NSCLC). Resource use information was obtained from a Phase III randomised trial investigating the efficacy and toxicity of gemcitabine/cisplatin (Gem/Cis), paclitaxel/carboplatin (Pac/Carbo) and vinorelbine/cisplatin (Vin/Cis) combination regimens in 612 patients with advanced NSCLC. Since there were no statistically significant differences between the three treatments in terms of progression-free or overall survival in this trial, a cost-minimisation analysis was considered to be the appropriate type of economic evaluation. The perspective was that of the national healthcare provider in Italy. Medical resource use was obtained from the clinical trial database, from which mean cost streams were calculated for each treatment group. The mean total treatment costs per patient were €8094, €11,203 and €9320 for the Gem/Cis, Pac/Carbo and Vin/Cis regimens, respectively. Based on resource consumption in a clinical trial, Gem/Cis had the lowest overall mean costs of the three chemotherapy regimens. Gem/Cis therefore has the potential to save costs in the treatment of advanced NSCLC in Italy.

Original languageEnglish
Pages (from-to)379-387
Number of pages9
JournalLung Cancer
Volume48
Issue number3
DOIs
Publication statusPublished - Jun 2005

Keywords

  • Chemotherapy
  • Cost-minimisation
  • Gemcitabine
  • Non-small cell lung cancer
  • Paclitaxel
  • Pharmacoeconomics
  • Vinorelbine

ASJC Scopus subject areas

  • Oncology

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    Novello, S., Kielhorn, A., Stynes, G., Selvaggi, G., De Marinis, F., Maestri, A., Foggi, P., Tilden, D., Tonato, M., Crinò, L., Rinaldi, M., Migliorino, A. M., & Scagliotti, G. V. (2005). Cost-minimisation analysis comparing gemcitabine/cisplatin, paclitaxel/carboplatin and vinorelbine/cisplatin in the treatment of advanced non-small cell lung cancer in Italy. Lung Cancer, 48(3), 379-387. https://doi.org/10.1016/j.lungcan.2004.11.014