Costs of bleeds relating to acute coronary syndrome therapies

Alexander Bufe, Ferrari Emile, Laurent Drogoul, Josep Guindo Soldevila, Di Pasquale Giuseppe, Lettino Maddalena, Magnus Janzon, Ruth E. Brown

Research output: Contribution to journalArticlepeer-review


Objective: To estimate the costs to manage selected types of bleeding complications in patients with acute coronary syndrome (ACS) treated with antithrombotics, including antiplatelet, and fibrinolytic therapies: decrease in haemoglobin >3 g/dL, puncture site, and bleeding requiring transfusion of blood products. Methods: Retrospective chart reviews of ACS patients experiencing decrease in Hb, puncture site, or bleeding requiring transfusion were conducted in hospitals in France, Germany, Italy, Spain and Sweden to determine the total length of stay (LOS), stay post-bleeding, procedures to identify the extent of bleeding, number and types of transfusion products, patient demographics, reason for hospital admission and disposition upon discharge. Country-specific costs were applied to estimate the average cost per patient by type of bleeding event. Results: Records of 158 ACS patients with the bleeding complications were examined (26.9 decrease in Hb, 35.5 puncture site, and 37.8 transfusion). The average LOS was 10.6 days for decreasing Hb, 7.7 days for puncture site bleeding, and 11.3 days for patients receiving transfusions due to these bleeding events. The average costs per patient ranged between €3,986 and €10,252. The LOS ranged widely both within and across countries. Limitations: The study has a small sample size and costs are confounded by co-morbidities. Conclusions: The estimated costs for decreasing Hb, puncture site bleeding and bleeding resulting in transfusions provide a tool for researchers to conduct economic analyses of bleeding events associated with therapies for ACS.

Original languageEnglish
Pages (from-to)236-240
Number of pages5
JournalJournal of Medical Economics
Issue number2
Publication statusPublished - Jun 2010


  • Acute coronary syndrome
  • Bleeds
  • Costs

ASJC Scopus subject areas

  • Health Policy


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