TY - JOUR
T1 - Cotard parasomnia
T2 - Le délire de negation that occur during the sleep-wake dissociation?
AU - Gnoni, Valentina
AU - Higgins, Sean
AU - Nesbitt, Alexander David
AU - Wasserman, Danielle
AU - Duncan, Iain
AU - Birdseye, Adam
AU - Pérez-Carbonell, Laura
AU - Drakatos, Panagis
AU - Koutramanidis, Michaelis
AU - Ferini-Strambi, Luigi
AU - Leschziner, Guy Doron
AU - Rosenzweig, Ivana
N1 - Funding Information:
All authors approved the last draft of this manuscript. All authors were involved in reviewing and drafting of the manuscript. The authors declare no conflict of interest.
Publisher Copyright:
Copyright © 2020 American Academy of Sleep Medicine. All rights reserved.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/6/15
Y1 - 2020/6/15
N2 - Unpleasant dreamlike mentation can occur during non-rapid eye movement parasomnias, leading to associated panic attacks. The mentations are rarely remembered and are likely underreported. However, they may lead to significant personal distress and, if not addressed, may contribute to poorer clinical outcomes. Cotard le délire de negation are very rare nihilistic delusions, historically described with psychotic disorders. Their association with a variety of neurologic disorders, including migraine and cluster-headache, has also been reported. Here we present three cases of Cotard parasomnia during which distinct states of consciousness defined by nihilistic ideation occurred. Patients described believing they are dead or dying, while unable to perceive or experience their bodies in whole, or in part, as their own. A source analysis of the electroencephalographic fingerprint of these mentations suggests right-hemispheric hypoactivity subsequent to confusional arousals. Mechanistically, an aberrant activation of two major intrinsic brain networks of wakefulness, the salience network and the default mode network, is argued.
AB - Unpleasant dreamlike mentation can occur during non-rapid eye movement parasomnias, leading to associated panic attacks. The mentations are rarely remembered and are likely underreported. However, they may lead to significant personal distress and, if not addressed, may contribute to poorer clinical outcomes. Cotard le délire de negation are very rare nihilistic delusions, historically described with psychotic disorders. Their association with a variety of neurologic disorders, including migraine and cluster-headache, has also been reported. Here we present three cases of Cotard parasomnia during which distinct states of consciousness defined by nihilistic ideation occurred. Patients described believing they are dead or dying, while unable to perceive or experience their bodies in whole, or in part, as their own. A source analysis of the electroencephalographic fingerprint of these mentations suggests right-hemispheric hypoactivity subsequent to confusional arousals. Mechanistically, an aberrant activation of two major intrinsic brain networks of wakefulness, the salience network and the default mode network, is argued.
KW - Cotard delusion
KW - Default mode network
KW - EEG
KW - Major intrinsic networks
KW - Non-REM parasomnia
KW - Salience network
KW - Sleep
KW - Sleep-wake transition
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U2 - 10.5664/jcsm.8430
DO - 10.5664/jcsm.8430
M3 - Article
C2 - 32195661
AN - SCOPUS:85086682479
VL - 16
SP - 971
EP - 976
JO - Journal of Clinical Sleep Medicine
JF - Journal of Clinical Sleep Medicine
SN - 1550-9389
IS - 6
ER -