Could cell kinetics be a predictor of prognosis in non-small cell lung cancer?

Rosella Silvestrini, Giuseppe Muscolino, Aurora Costa, Cosimo Lequaglie, Silvia Veneroni, Guerrino Mezzanotte, Gianni Ravasi

Research output: Contribution to journalArticle

Abstract

Cell kinetics, evaluated as 3H-thymidine labeling index ([3H]TdR LI), was assessed in 72 previously untreated non-small-cell lung cancers (NSCLC) from patients operated on during the period 1978 to 1982 at the Istituto Nazionale Tumori of Milan. Pathologic stage and histology, but not tumor size or cell kinetics, were indicative of clinical outcome on the overall series. However, in stage I patients, relapse-free survival and overall survival were significantly higher for patients with low [3H]TdR LI or squamous cell tumors than for patients with high [3H]TdR LI or non-squamous cell tumors. When both cell kinetics and histology were taken into consideration, the probability of 5-year survival was 100% for patients with slowly proliferating squamous cell carcinomas compared to only 29% for patients with rapidly proliferating non-squamous cell carcinomas. The data suggest that cell kinetics and histology could represent an important means to identify a subgroup of patients with high risk of relapse within stage I NSCLC.

Original languageEnglish
Pages (from-to)165-170
Number of pages6
JournalLung Cancer
Volume7
Issue number3
DOIs
Publication statusPublished - 1991

Fingerprint

Non-Small Cell Lung Carcinoma
Histology
Survival
Recurrence
Neoplasms
Cell Size
Thymidine
Squamous Cell Carcinoma
Epithelial Cells
Carcinoma

Keywords

  • Cell kinetics
  • Non-small cell lung cancer
  • Prognosis

ASJC Scopus subject areas

  • Oncology

Cite this

Silvestrini, R., Muscolino, G., Costa, A., Lequaglie, C., Veneroni, S., Mezzanotte, G., & Ravasi, G. (1991). Could cell kinetics be a predictor of prognosis in non-small cell lung cancer? Lung Cancer, 7(3), 165-170. https://doi.org/10.1016/0169-5002(91)90075-H

Could cell kinetics be a predictor of prognosis in non-small cell lung cancer? / Silvestrini, Rosella; Muscolino, Giuseppe; Costa, Aurora; Lequaglie, Cosimo; Veneroni, Silvia; Mezzanotte, Guerrino; Ravasi, Gianni.

In: Lung Cancer, Vol. 7, No. 3, 1991, p. 165-170.

Research output: Contribution to journalArticle

Silvestrini, R, Muscolino, G, Costa, A, Lequaglie, C, Veneroni, S, Mezzanotte, G & Ravasi, G 1991, 'Could cell kinetics be a predictor of prognosis in non-small cell lung cancer?', Lung Cancer, vol. 7, no. 3, pp. 165-170. https://doi.org/10.1016/0169-5002(91)90075-H
Silvestrini, Rosella ; Muscolino, Giuseppe ; Costa, Aurora ; Lequaglie, Cosimo ; Veneroni, Silvia ; Mezzanotte, Guerrino ; Ravasi, Gianni. / Could cell kinetics be a predictor of prognosis in non-small cell lung cancer?. In: Lung Cancer. 1991 ; Vol. 7, No. 3. pp. 165-170.
@article{6b48fb240af9466bb54c03388096e736,
title = "Could cell kinetics be a predictor of prognosis in non-small cell lung cancer?",
abstract = "Cell kinetics, evaluated as 3H-thymidine labeling index ([3H]TdR LI), was assessed in 72 previously untreated non-small-cell lung cancers (NSCLC) from patients operated on during the period 1978 to 1982 at the Istituto Nazionale Tumori of Milan. Pathologic stage and histology, but not tumor size or cell kinetics, were indicative of clinical outcome on the overall series. However, in stage I patients, relapse-free survival and overall survival were significantly higher for patients with low [3H]TdR LI or squamous cell tumors than for patients with high [3H]TdR LI or non-squamous cell tumors. When both cell kinetics and histology were taken into consideration, the probability of 5-year survival was 100{\%} for patients with slowly proliferating squamous cell carcinomas compared to only 29{\%} for patients with rapidly proliferating non-squamous cell carcinomas. The data suggest that cell kinetics and histology could represent an important means to identify a subgroup of patients with high risk of relapse within stage I NSCLC.",
keywords = "Cell kinetics, Non-small cell lung cancer, Prognosis",
author = "Rosella Silvestrini and Giuseppe Muscolino and Aurora Costa and Cosimo Lequaglie and Silvia Veneroni and Guerrino Mezzanotte and Gianni Ravasi",
year = "1991",
doi = "10.1016/0169-5002(91)90075-H",
language = "English",
volume = "7",
pages = "165--170",
journal = "Lung Cancer",
issn = "0169-5002",
publisher = "Elsevier Ireland Ltd",
number = "3",

}

TY - JOUR

T1 - Could cell kinetics be a predictor of prognosis in non-small cell lung cancer?

AU - Silvestrini, Rosella

AU - Muscolino, Giuseppe

AU - Costa, Aurora

AU - Lequaglie, Cosimo

AU - Veneroni, Silvia

AU - Mezzanotte, Guerrino

AU - Ravasi, Gianni

PY - 1991

Y1 - 1991

N2 - Cell kinetics, evaluated as 3H-thymidine labeling index ([3H]TdR LI), was assessed in 72 previously untreated non-small-cell lung cancers (NSCLC) from patients operated on during the period 1978 to 1982 at the Istituto Nazionale Tumori of Milan. Pathologic stage and histology, but not tumor size or cell kinetics, were indicative of clinical outcome on the overall series. However, in stage I patients, relapse-free survival and overall survival were significantly higher for patients with low [3H]TdR LI or squamous cell tumors than for patients with high [3H]TdR LI or non-squamous cell tumors. When both cell kinetics and histology were taken into consideration, the probability of 5-year survival was 100% for patients with slowly proliferating squamous cell carcinomas compared to only 29% for patients with rapidly proliferating non-squamous cell carcinomas. The data suggest that cell kinetics and histology could represent an important means to identify a subgroup of patients with high risk of relapse within stage I NSCLC.

AB - Cell kinetics, evaluated as 3H-thymidine labeling index ([3H]TdR LI), was assessed in 72 previously untreated non-small-cell lung cancers (NSCLC) from patients operated on during the period 1978 to 1982 at the Istituto Nazionale Tumori of Milan. Pathologic stage and histology, but not tumor size or cell kinetics, were indicative of clinical outcome on the overall series. However, in stage I patients, relapse-free survival and overall survival were significantly higher for patients with low [3H]TdR LI or squamous cell tumors than for patients with high [3H]TdR LI or non-squamous cell tumors. When both cell kinetics and histology were taken into consideration, the probability of 5-year survival was 100% for patients with slowly proliferating squamous cell carcinomas compared to only 29% for patients with rapidly proliferating non-squamous cell carcinomas. The data suggest that cell kinetics and histology could represent an important means to identify a subgroup of patients with high risk of relapse within stage I NSCLC.

KW - Cell kinetics

KW - Non-small cell lung cancer

KW - Prognosis

UR - http://www.scopus.com/inward/record.url?scp=0025877829&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025877829&partnerID=8YFLogxK

U2 - 10.1016/0169-5002(91)90075-H

DO - 10.1016/0169-5002(91)90075-H

M3 - Article

AN - SCOPUS:0025877829

VL - 7

SP - 165

EP - 170

JO - Lung Cancer

JF - Lung Cancer

SN - 0169-5002

IS - 3

ER -