Abstract
Cell kinetics, evaluated as 3H-thymidine labeling index ([3H]TdR LI), was assessed in 72 previously untreated non-small-cell lung cancers (NSCLC) from patients operated on during the period 1978 to 1982 at the Istituto Nazionale Tumori of Milan. Pathologic stage and histology, but not tumor size or cell kinetics, were indicative of clinical outcome on the overall series. However, in stage I patients, relapse-free survival and overall survival were significantly higher for patients with low [3H]TdR LI or squamous cell tumors than for patients with high [3H]TdR LI or non-squamous cell tumors. When both cell kinetics and histology were taken into consideration, the probability of 5-year survival was 100% for patients with slowly proliferating squamous cell carcinomas compared to only 29% for patients with rapidly proliferating non-squamous cell carcinomas. The data suggest that cell kinetics and histology could represent an important means to identify a subgroup of patients with high risk of relapse within stage I NSCLC.
| Original language | English |
|---|---|
| Pages (from-to) | 165-170 |
| Number of pages | 6 |
| Journal | Lung Cancer |
| Volume | 7 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 1991 |
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Keywords
- Cell kinetics
- Non-small cell lung cancer
- Prognosis
ASJC Scopus subject areas
- Oncology
Cite this
Could cell kinetics be a predictor of prognosis in non-small cell lung cancer? / Silvestrini, Rosella; Muscolino, Giuseppe; Costa, Aurora; Lequaglie, Cosimo; Veneroni, Silvia; Mezzanotte, Guerrino; Ravasi, Gianni.
In: Lung Cancer, Vol. 7, No. 3, 1991, p. 165-170.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Could cell kinetics be a predictor of prognosis in non-small cell lung cancer?
AU - Silvestrini, Rosella
AU - Muscolino, Giuseppe
AU - Costa, Aurora
AU - Lequaglie, Cosimo
AU - Veneroni, Silvia
AU - Mezzanotte, Guerrino
AU - Ravasi, Gianni
PY - 1991
Y1 - 1991
N2 - Cell kinetics, evaluated as 3H-thymidine labeling index ([3H]TdR LI), was assessed in 72 previously untreated non-small-cell lung cancers (NSCLC) from patients operated on during the period 1978 to 1982 at the Istituto Nazionale Tumori of Milan. Pathologic stage and histology, but not tumor size or cell kinetics, were indicative of clinical outcome on the overall series. However, in stage I patients, relapse-free survival and overall survival were significantly higher for patients with low [3H]TdR LI or squamous cell tumors than for patients with high [3H]TdR LI or non-squamous cell tumors. When both cell kinetics and histology were taken into consideration, the probability of 5-year survival was 100% for patients with slowly proliferating squamous cell carcinomas compared to only 29% for patients with rapidly proliferating non-squamous cell carcinomas. The data suggest that cell kinetics and histology could represent an important means to identify a subgroup of patients with high risk of relapse within stage I NSCLC.
AB - Cell kinetics, evaluated as 3H-thymidine labeling index ([3H]TdR LI), was assessed in 72 previously untreated non-small-cell lung cancers (NSCLC) from patients operated on during the period 1978 to 1982 at the Istituto Nazionale Tumori of Milan. Pathologic stage and histology, but not tumor size or cell kinetics, were indicative of clinical outcome on the overall series. However, in stage I patients, relapse-free survival and overall survival were significantly higher for patients with low [3H]TdR LI or squamous cell tumors than for patients with high [3H]TdR LI or non-squamous cell tumors. When both cell kinetics and histology were taken into consideration, the probability of 5-year survival was 100% for patients with slowly proliferating squamous cell carcinomas compared to only 29% for patients with rapidly proliferating non-squamous cell carcinomas. The data suggest that cell kinetics and histology could represent an important means to identify a subgroup of patients with high risk of relapse within stage I NSCLC.
KW - Cell kinetics
KW - Non-small cell lung cancer
KW - Prognosis
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UR - http://www.scopus.com/inward/citedby.url?scp=0025877829&partnerID=8YFLogxK
U2 - 10.1016/0169-5002(91)90075-H
DO - 10.1016/0169-5002(91)90075-H
M3 - Article
AN - SCOPUS:0025877829
VL - 7
SP - 165
EP - 170
JO - Lung Cancer
JF - Lung Cancer
SN - 0169-5002
IS - 3
ER -