Could we also be regenerative superheroes, like salamanders?

Alessandra Dall'Agnese, Pier Lorenzo Puri

Research output: Contribution to journalReview articlepeer-review

Abstract

Development of methods to reawaken the semi-dormant regenerative potential that lies within adult human tissues would hold promise for the restoration of diseased or damaged organs and tissues. While most of the regeneration potential is suppressed in many vertebrates, including humans, during adult life, urodele amphibians (salamanders) retain their regenerative ability throughout adulthood. Studies in newts and axolotls, two salamander models, have provided significant knowledge about adult limb regeneration. In this review, we present a comparative analysis of salamander and mammalian regeneration and discuss how evolutionarily altered properties of the regenerative environment can be exploited to restore full regenerative potential in the human body.

Original languageEnglish
Pages (from-to)917-926
Number of pages10
JournalBioEssays
Volume38
Issue number9
DOIs
Publication statusPublished - Sep 1 2016

Keywords

  • axolotl
  • fibrosis
  • metamorphosis
  • newt
  • regeneration

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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