Coupled plasma filtration adsorption in patients with a history of kidney transplantation: Report of two cases

Quirino Lai, Verdiana Di Pietro, Samuele Iesari, Sofia Amabili, Linda De Luca, Katia Clemente, Antonio Famulari, Francesco Pisani

Research output: Contribution to journalArticle

Abstract

Coupled plasma filtration adsorption (CPFA) is an extracorporeal treatment based on plasma filtration associated with an adsorbent cartridge and hemofiltration. CPFA is able to remove inflammatory mediators and it has been used to treat severe sepsis, septic shock and multiple organ dysfunction syndrome. Limited experience exists on the use of CPFA after solid organ transplantation. We report our experience with CPFA in 2 kidney transplant recipients with post-nephrolithotomy septic shock and severe unexplained rhabdomyolysis. In both the cases, excellent results were observed. In selected cases, CPFA can be safely and effectively used in patients with a solid organ transplant. However, additional studies are needed in this particular setting, to further investigate the potential role of CPFA for the treatment of other conditions associated with excessive inflammation, such as in rheumatologic disorders and delayed graft function.

Original languageEnglish
Pages (from-to)218-222
Number of pages5
JournalBlood Purification
Volume40
Issue number3
DOIs
Publication statusPublished - Oct 1 2015

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Keywords

  • Cytokines
  • Graft survival
  • Myoglobin
  • Rhabdomyolysis
  • Sepsis

ASJC Scopus subject areas

  • Nephrology
  • Hematology

Cite this

Lai, Q., Di Pietro, V., Iesari, S., Amabili, S., De Luca, L., Clemente, K., Famulari, A., & Pisani, F. (2015). Coupled plasma filtration adsorption in patients with a history of kidney transplantation: Report of two cases. Blood Purification, 40(3), 218-222. https://doi.org/10.1159/000437042