Abstract
The goal of this study was the in vivo evaluation of nanoporous titanium (Ti) implants bearing a covalently linked surface hyaluronan (HA) layer. Implant surface topography and surface chemistry were previously evaluated by scanning electron micorscopy and X-ray photoelectron spectroscopy. Results showed that the surface modification process did not affect surface topography, yielding a homogeneously HA-coated nanotextured implant surface. In vivo evaluation of implants in both cortical and trabecular bone of rabbit femurs showed a significant improvement of both bone-to-implant contact and bone ingrowth at HA-bearing implant interfaces at 4 weeks. The improvement in osteointegration rate was particularly evident in the marrow-rich trabecular bone (bone-to-implant contact: control 22.5%; HA-coated 69.0%, p <0.01). Mechanical testing (push-out test) and evaluation of interfacial bone microhardness confirmed a faster bone maturation around HA-coated implants (Bone Maturation Index: control 79.1%; HA-coated 90.6%, p <0.05). Suggestions based on the biochemical role of HA are presented to account for the observed behavior.
Original language | English |
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Pages (from-to) | 657-663 |
Number of pages | 7 |
Journal | Journal of Orthopaedic Research |
Volume | 27 |
Issue number | 5 |
DOIs | |
Publication status | Published - May 2009 |
Keywords
- Biochemical modifcation of Ti surfaces
- Bone implants
- Hyaluronan
- Osteointegration
ASJC Scopus subject areas
- Orthopedics and Sports Medicine
- Medicine(all)