TY - JOUR
T1 - COVID-19 and ECMO
T2 - the interplay between coagulation and inflammation-a narrative review
AU - Kowalewski, Mariusz
AU - Fina, Dario
AU - Słomka, Artur
AU - Raffa, Giuseppe Maria
AU - Martucci, Gennaro
AU - Lo Coco, Valeria
AU - De Piero, Maria Elena
AU - Ranucci, Marco
AU - Suwalski, Piotr
AU - Lorusso, Roberto
PY - 2020/5/8
Y1 - 2020/5/8
N2 - Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has presently become a rapidly spreading and devastating global pandemic. Veno-venous extracorporeal membrane oxygenation (V-V ECMO) may serve as life-saving rescue therapy for refractory respiratory failure in the setting of acute respiratory compromise such as that induced by SARS-CoV-2. While still little is known on the true efficacy of ECMO in this setting, the natural resemblance of seasonal influenza's characteristics with respect to acute onset, initial symptoms, and some complications prompt to ECMO implantation in most severe, pulmonary decompensated patients. The present review summarizes the evidence on ECMO management of severe ARDS in light of recent COVID-19 pandemic, at the same time focusing on differences and similarities between SARS-CoV-2 and ECMO in terms of hematological and inflammatory interplay when these two settings merge.
AB - Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has presently become a rapidly spreading and devastating global pandemic. Veno-venous extracorporeal membrane oxygenation (V-V ECMO) may serve as life-saving rescue therapy for refractory respiratory failure in the setting of acute respiratory compromise such as that induced by SARS-CoV-2. While still little is known on the true efficacy of ECMO in this setting, the natural resemblance of seasonal influenza's characteristics with respect to acute onset, initial symptoms, and some complications prompt to ECMO implantation in most severe, pulmonary decompensated patients. The present review summarizes the evidence on ECMO management of severe ARDS in light of recent COVID-19 pandemic, at the same time focusing on differences and similarities between SARS-CoV-2 and ECMO in terms of hematological and inflammatory interplay when these two settings merge.
KW - Betacoronavirus
KW - Blood Coagulation
KW - COVID-19
KW - Coronavirus Infections/blood
KW - Cytokine Release Syndrome
KW - Extracorporeal Membrane Oxygenation
KW - Pandemics
KW - Pneumonia, Viral/blood
KW - SARS-CoV-2
KW - Severe Acute Respiratory Syndrome/blood
KW - Thrombocytopenia
U2 - 10.1186/s13054-020-02925-3
DO - 10.1186/s13054-020-02925-3
M3 - Article
VL - 24
JO - Crit Care
JF - Crit Care
SN - 1466-609X
IS - 1
ER -