TY - JOUR
T1 - COVID-19 in lung transplant recipients
T2 - A case series from Milan, Italy
AU - Morlacchi, Letizia Corinna
AU - Rossetti, Valeria
AU - Gigli, Lorenzo
AU - Amati, Francesco
AU - Rosso, Lorenzo
AU - Aliberti, Stefano
AU - Nosotti, Mario
AU - Blasi, Francesco
PY - 2020
Y1 - 2020
N2 - Limited data are currently available regarding the course of COVID-19 in lung and solid organ transplant recipients. We hereby present four cases of SARS-CoV-2 pneumonia in lung transplant recipients from our center, set in Milan, Italy. We reduced immunosuppressive regimen in all these patients, typically holding the antiproliferative agent and augmenting steroids; everybody received hydroxychloroquine, initial empiric antibiotic treatment with piperacillin/tazobactam, and high-dose low molecular weight heparin. Clinical course seemed favorable in three of our patients, but one of them deteriorated after 10 days of hospitalization, probably due to an acute form of graft dysfunction triggered both by COVID-19 and a nosocomial bacterial infection, and eventually died. Although short-term prognosis could be considered benign in the majority of our patients, we should carefully monitor these individuals in order to detect early sign of clinical deterioration and graft dysfunction in the next few months.
AB - Limited data are currently available regarding the course of COVID-19 in lung and solid organ transplant recipients. We hereby present four cases of SARS-CoV-2 pneumonia in lung transplant recipients from our center, set in Milan, Italy. We reduced immunosuppressive regimen in all these patients, typically holding the antiproliferative agent and augmenting steroids; everybody received hydroxychloroquine, initial empiric antibiotic treatment with piperacillin/tazobactam, and high-dose low molecular weight heparin. Clinical course seemed favorable in three of our patients, but one of them deteriorated after 10 days of hospitalization, probably due to an acute form of graft dysfunction triggered both by COVID-19 and a nosocomial bacterial infection, and eventually died. Although short-term prognosis could be considered benign in the majority of our patients, we should carefully monitor these individuals in order to detect early sign of clinical deterioration and graft dysfunction in the next few months.
UR - http://www.scopus.com/inward/record.url?scp=85087216751&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85087216751&partnerID=8YFLogxK
U2 - 10.1111/tid.13356
DO - 10.1111/tid.13356
M3 - Article
C2 - 32510771
AN - SCOPUS:85087216751
VL - 22
JO - Transplant Infectious Disease
JF - Transplant Infectious Disease
SN - 1398-2273
IS - 6
M1 - e13356
ER -