COVID-19: Pharmacology and kinetics of viral clearance

Nicola Farina, Giuseppe A. Ramirez, Rebecca De Lorenzo, Luigi Di Filippo, Caterina Conte, Fabio Ciceri, Angelo A. Manfredi, Patrizia Rovere-Querini

Research output: Contribution to journalReview articlepeer-review

Abstract

Coronavirus Disease 2019 (COVID-19) is a pandemic disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The clinical spectrum of COVID-19 is broad and varies from mild to severe forms complicated by acute respiratory distress and death. This heterogeneity might reflect the ability of the host immune system to interact with SARS-CoV2 or the characteristics of the virus itself in terms of loads or persistence. Information on this issue might derive from interventional studies. However, results from high-quality trials are scarce. Here we evaluate the level of evidence of available published interventional studies, with a focus on randomised controlled trials and the efficacy of therapies on clinical outcomes. Moreover, we present data on a large cohort of well-characterized patients hospitalized at a single University Hospital in Milano (Italy), correlating viral clearance with clinical and biochemical features of patients.

Original languageEnglish
Article number105114
JournalPharmacological Research
Volume161
DOIs
Publication statusPublished - Nov 2020

Keywords

  • COVID-19
  • Pharmacology
  • SARS-CoV-2
  • Viral clearance kinetics

ASJC Scopus subject areas

  • Pharmacology

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