COVID-19-related and not related Guillain-Barré syndromes share the same management pitfalls during lock down: The experience of Liguria region in Italy

Martina Garnero, Massimo Del Sette, Andrea Assini, Alessandro Beronio, Elisabetta Capello, Corrado Cabona, Lizia Reni, Carlo Serrati, Fabio Bandini, Alfredo Granata, Giampaola Pesce, Giovanni L. Mancardi, Antonio Uccelli, Angelo Schenone, Luana Benedetti

Research output: Contribution to journalArticlepeer-review

Abstract

Recently, during the pandemic infection of the novel SARS-CoV-2, some cases of Guillan-Barré Syndrome (GBS) have been reported. The aim of this work is to report the natural history of patients with GBS, both COVID and not-COVID related, hospitalized in Liguria region, during lock down period, in order to assess clinical features of both groups and possible managements pitfalls due to pandemic emergency. Fifteen GBS patients were admitted to the Hospitals of Liguria, from February 15th to May 3rd 2020, six with SARS-CoV-2 infection and nine without infection. In COVID-19 related GBS five patients presented with classical GBS and one with variant. Two patients presented neurologic symptoms during or shortly after the viral syndrome, suggesting the pattern of a para-infectious profile. Multi-organ involvement, delay in the diagnosis, incomplete work up and start of therapy, were registered in 50% of cases with a GBS-Disability scale ≥4 at follow-up evaluation. In not-COVID-19 related GBS, main problem was diagnostic delay. In three patients the first neurological observation took place after a mean of 33,6 days. Moreover, five patients went to emergency room after an average of 30 days since the onset of neurological symptoms because of fear of contagion. In conclusion, not only SARS-CoV-2 infection can cause GBS, but it can also, due to effects of pandemic on the health organization, affect the outcome of patients with not COVID-19 related GBS.

Original languageEnglish
Article number117114
JournalJournal of the Neurological Sciences
Volume418
DOIs
Publication statusPublished - Nov 15 2020

Keywords

  • AIDP
  • AMAN
  • COVID-19
  • Guillain-Barré syndrome
  • Miller Fisher

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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