COX-2 overexpression in canine tumors: Potential therapeutic targets in oncology

Enrico P. Spugnini, A. Porrello, G. Citro, A. Baldi

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Cyclooxygenases catalyze the initial, rate-limiting steps of prostaglandin synthesis from arachidonic acid. Two isoforms of this enzyme exist in mammalian and avian species: COX-1 and COX-2. COX-1 is constitutively expressed and is the major isoform of gastrointestinal tissue. COX-2 is induced in response to inflammatory stimuli. COX-2 has been implicated in carcinogenesis of several neoplasms. Furthermore, COX-2 over-expression has been noted in many solid tumours and has been correlated with a worse prognosis in colorectal cancer, non-small-cell lung cancer, mesothelioma and gastric cancer. In this review, the most recent findings on the mechanisms by which COX-2 promote tumorigenesis are discussed, with particular emphasis on the studies involving spontaneous canine neoplasms.

Original languageEnglish
Pages (from-to)1309-1312
Number of pages4
JournalHistology and Histopathology
Volume20
Issue number4
Publication statusPublished - Oct 2005

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Canidae
Stomach Neoplasms
Protein Isoforms
Carcinogenesis
Neoplasms
Mesothelioma
Prostaglandin-Endoperoxide Synthases
Arachidonic Acid
Non-Small Cell Lung Carcinoma
Prostaglandins
Colorectal Neoplasms
Therapeutics
Enzymes

Keywords

  • Canine tumors
  • Chemotherapy
  • COX-2

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Histology
  • Cell Biology

Cite this

Spugnini, E. P., Porrello, A., Citro, G., & Baldi, A. (2005). COX-2 overexpression in canine tumors: Potential therapeutic targets in oncology. Histology and Histopathology, 20(4), 1309-1312.

COX-2 overexpression in canine tumors : Potential therapeutic targets in oncology. / Spugnini, Enrico P.; Porrello, A.; Citro, G.; Baldi, A.

In: Histology and Histopathology, Vol. 20, No. 4, 10.2005, p. 1309-1312.

Research output: Contribution to journalArticle

Spugnini, EP, Porrello, A, Citro, G & Baldi, A 2005, 'COX-2 overexpression in canine tumors: Potential therapeutic targets in oncology', Histology and Histopathology, vol. 20, no. 4, pp. 1309-1312.
Spugnini EP, Porrello A, Citro G, Baldi A. COX-2 overexpression in canine tumors: Potential therapeutic targets in oncology. Histology and Histopathology. 2005 Oct;20(4):1309-1312.
Spugnini, Enrico P. ; Porrello, A. ; Citro, G. ; Baldi, A. / COX-2 overexpression in canine tumors : Potential therapeutic targets in oncology. In: Histology and Histopathology. 2005 ; Vol. 20, No. 4. pp. 1309-1312.
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