Abstract
Cyclooxygenases catalyze the initial, rate-limiting steps of prostaglandin synthesis from arachidonic acid. Two isoforms of this enzyme exist in mammalian and avian species: COX-1 and COX-2. COX-1 is constitutively expressed and is the major isoform of gastrointestinal tissue. COX-2 is induced in response to inflammatory stimuli. COX-2 has been implicated in carcinogenesis of several neoplasms. Furthermore, COX-2 over-expression has been noted in many solid tumours and has been correlated with a worse prognosis in colorectal cancer, non-small-cell lung cancer, mesothelioma and gastric cancer. In this review, the most recent findings on the mechanisms by which COX-2 promote tumorigenesis are discussed, with particular emphasis on the studies involving spontaneous canine neoplasms.
| Original language | English |
|---|---|
| Pages (from-to) | 1309-1312 |
| Number of pages | 4 |
| Journal | Histology and Histopathology |
| Volume | 20 |
| Issue number | 4 |
| Publication status | Published - Oct 2005 |
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Keywords
- Canine tumors
- Chemotherapy
- COX-2
ASJC Scopus subject areas
- Anatomy
- Pathology and Forensic Medicine
- Histology
- Cell Biology
Cite this
COX-2 overexpression in canine tumors : Potential therapeutic targets in oncology. / Spugnini, Enrico P.; Porrello, A.; Citro, G.; Baldi, A.
In: Histology and Histopathology, Vol. 20, No. 4, 10.2005, p. 1309-1312.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - COX-2 overexpression in canine tumors
T2 - Potential therapeutic targets in oncology
AU - Spugnini, Enrico P.
AU - Porrello, A.
AU - Citro, G.
AU - Baldi, A.
PY - 2005/10
Y1 - 2005/10
N2 - Cyclooxygenases catalyze the initial, rate-limiting steps of prostaglandin synthesis from arachidonic acid. Two isoforms of this enzyme exist in mammalian and avian species: COX-1 and COX-2. COX-1 is constitutively expressed and is the major isoform of gastrointestinal tissue. COX-2 is induced in response to inflammatory stimuli. COX-2 has been implicated in carcinogenesis of several neoplasms. Furthermore, COX-2 over-expression has been noted in many solid tumours and has been correlated with a worse prognosis in colorectal cancer, non-small-cell lung cancer, mesothelioma and gastric cancer. In this review, the most recent findings on the mechanisms by which COX-2 promote tumorigenesis are discussed, with particular emphasis on the studies involving spontaneous canine neoplasms.
AB - Cyclooxygenases catalyze the initial, rate-limiting steps of prostaglandin synthesis from arachidonic acid. Two isoforms of this enzyme exist in mammalian and avian species: COX-1 and COX-2. COX-1 is constitutively expressed and is the major isoform of gastrointestinal tissue. COX-2 is induced in response to inflammatory stimuli. COX-2 has been implicated in carcinogenesis of several neoplasms. Furthermore, COX-2 over-expression has been noted in many solid tumours and has been correlated with a worse prognosis in colorectal cancer, non-small-cell lung cancer, mesothelioma and gastric cancer. In this review, the most recent findings on the mechanisms by which COX-2 promote tumorigenesis are discussed, with particular emphasis on the studies involving spontaneous canine neoplasms.
KW - Canine tumors
KW - Chemotherapy
KW - COX-2
UR - http://www.scopus.com/inward/record.url?scp=27144435529&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=27144435529&partnerID=8YFLogxK
M3 - Article
C2 - 16136511
AN - SCOPUS:27144435529
VL - 20
SP - 1309
EP - 1312
JO - Histology and Histopathology
JF - Histology and Histopathology
SN - 0213-3911
IS - 4
ER -