COX-2 overexpression in canine tumors: Potential therapeutic targets in oncology

Enrico P. Spugnini, A. Porrello, G. Citro, A. Baldi

Research output: Contribution to journalArticlepeer-review

Abstract

Cyclooxygenases catalyze the initial, rate-limiting steps of prostaglandin synthesis from arachidonic acid. Two isoforms of this enzyme exist in mammalian and avian species: COX-1 and COX-2. COX-1 is constitutively expressed and is the major isoform of gastrointestinal tissue. COX-2 is induced in response to inflammatory stimuli. COX-2 has been implicated in carcinogenesis of several neoplasms. Furthermore, COX-2 over-expression has been noted in many solid tumours and has been correlated with a worse prognosis in colorectal cancer, non-small-cell lung cancer, mesothelioma and gastric cancer. In this review, the most recent findings on the mechanisms by which COX-2 promote tumorigenesis are discussed, with particular emphasis on the studies involving spontaneous canine neoplasms.

Original languageEnglish
Pages (from-to)1309-1312
Number of pages4
JournalHistology and Histopathology
Volume20
Issue number4
Publication statusPublished - Oct 2005

Keywords

  • Canine tumors
  • Chemotherapy
  • COX-2

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Histology
  • Cell Biology

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