Cox and mesothelioma: An overview

I. Cardillo, E. P. Spugnini, A. Verdina, R. Galati, G. Citro, Alfonso Baldi

Research output: Contribution to journalArticle

Abstract

Cyclooxygenases catalyze the rate limiting step in the production of prostanoids. Accumulating data demonstrate that overexpression of these enzymes, and in particular of cyclooxygenases-2, promotes multiple events involved in tumorigenesis; in addition, numerous studies show that inhibition of cyclooxygenases-2 can delay or prevent certain forms of cancer. Malignant mesothelioma is a lethal pleural, peritoneal and pericardial neoplasia that actually lacks valid therapies and in which cyclooxygenases-2 is recognized as an important adverse prognostic factor. Hence, there is an increasing interest in the development of new treatments based on cyclooxygenases-2 inhibitors, to prolong survival and even potentially cure this neoplasia.

Original languageEnglish
Pages (from-to)1267-1274
Number of pages8
JournalHistology and Histopathology
Volume20
Issue number4
Publication statusPublished - Oct 2005

Fingerprint

Mesothelioma
Cyclooxygenase 2
Neoplasms
Cyclooxygenase 2 Inhibitors
Prostaglandin-Endoperoxide Synthases
Prostaglandins
Carcinogenesis
Enzymes
Therapeutics

Keywords

  • Chemotherapy
  • COX-2
  • Mesothelioma

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Histology
  • Cell Biology

Cite this

Cardillo, I., Spugnini, E. P., Verdina, A., Galati, R., Citro, G., & Baldi, A. (2005). Cox and mesothelioma: An overview. Histology and Histopathology, 20(4), 1267-1274.

Cox and mesothelioma : An overview. / Cardillo, I.; Spugnini, E. P.; Verdina, A.; Galati, R.; Citro, G.; Baldi, Alfonso.

In: Histology and Histopathology, Vol. 20, No. 4, 10.2005, p. 1267-1274.

Research output: Contribution to journalArticle

Cardillo, I, Spugnini, EP, Verdina, A, Galati, R, Citro, G & Baldi, A 2005, 'Cox and mesothelioma: An overview', Histology and Histopathology, vol. 20, no. 4, pp. 1267-1274.
Cardillo I, Spugnini EP, Verdina A, Galati R, Citro G, Baldi A. Cox and mesothelioma: An overview. Histology and Histopathology. 2005 Oct;20(4):1267-1274.
Cardillo, I. ; Spugnini, E. P. ; Verdina, A. ; Galati, R. ; Citro, G. ; Baldi, Alfonso. / Cox and mesothelioma : An overview. In: Histology and Histopathology. 2005 ; Vol. 20, No. 4. pp. 1267-1274.
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