Abstract
Cyclooxygenases catalyze the rate limiting step in the production of prostanoids. Accumulating data demonstrate that overexpression of these enzymes, and in particular of cyclooxygenases-2, promotes multiple events involved in tumorigenesis; in addition, numerous studies show that inhibition of cyclooxygenases-2 can delay or prevent certain forms of cancer. Malignant mesothelioma is a lethal pleural, peritoneal and pericardial neoplasia that actually lacks valid therapies and in which cyclooxygenases-2 is recognized as an important adverse prognostic factor. Hence, there is an increasing interest in the development of new treatments based on cyclooxygenases-2 inhibitors, to prolong survival and even potentially cure this neoplasia.
| Original language | English |
|---|---|
| Pages (from-to) | 1267-1274 |
| Number of pages | 8 |
| Journal | Histology and Histopathology |
| Volume | 20 |
| Issue number | 4 |
| Publication status | Published - Oct 2005 |
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Keywords
- Chemotherapy
- COX-2
- Mesothelioma
ASJC Scopus subject areas
- Anatomy
- Pathology and Forensic Medicine
- Histology
- Cell Biology
Cite this
Cox and mesothelioma : An overview. / Cardillo, I.; Spugnini, E. P.; Verdina, A.; Galati, R.; Citro, G.; Baldi, Alfonso.
In: Histology and Histopathology, Vol. 20, No. 4, 10.2005, p. 1267-1274.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cox and mesothelioma
T2 - An overview
AU - Cardillo, I.
AU - Spugnini, E. P.
AU - Verdina, A.
AU - Galati, R.
AU - Citro, G.
AU - Baldi, Alfonso
PY - 2005/10
Y1 - 2005/10
N2 - Cyclooxygenases catalyze the rate limiting step in the production of prostanoids. Accumulating data demonstrate that overexpression of these enzymes, and in particular of cyclooxygenases-2, promotes multiple events involved in tumorigenesis; in addition, numerous studies show that inhibition of cyclooxygenases-2 can delay or prevent certain forms of cancer. Malignant mesothelioma is a lethal pleural, peritoneal and pericardial neoplasia that actually lacks valid therapies and in which cyclooxygenases-2 is recognized as an important adverse prognostic factor. Hence, there is an increasing interest in the development of new treatments based on cyclooxygenases-2 inhibitors, to prolong survival and even potentially cure this neoplasia.
AB - Cyclooxygenases catalyze the rate limiting step in the production of prostanoids. Accumulating data demonstrate that overexpression of these enzymes, and in particular of cyclooxygenases-2, promotes multiple events involved in tumorigenesis; in addition, numerous studies show that inhibition of cyclooxygenases-2 can delay or prevent certain forms of cancer. Malignant mesothelioma is a lethal pleural, peritoneal and pericardial neoplasia that actually lacks valid therapies and in which cyclooxygenases-2 is recognized as an important adverse prognostic factor. Hence, there is an increasing interest in the development of new treatments based on cyclooxygenases-2 inhibitors, to prolong survival and even potentially cure this neoplasia.
KW - Chemotherapy
KW - COX-2
KW - Mesothelioma
UR - http://www.scopus.com/inward/record.url?scp=27144440088&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=27144440088&partnerID=8YFLogxK
M3 - Article
C2 - 16136507
AN - SCOPUS:27144440088
VL - 20
SP - 1267
EP - 1274
JO - Histology and Histopathology
JF - Histology and Histopathology
SN - 0213-3911
IS - 4
ER -