Abstract
Cyclooxygenases catalyze the rate limiting step in the production of prostanoids. Accumulating data demonstrate that overexpression of these enzymes, and in particular of cyclooxygenases-2, promotes multiple events involved in tumorigenesis; in addition, numerous studies show that inhibition of cyclooxygenases-2 can delay or prevent certain forms of cancer. Malignant mesothelioma is a lethal pleural, peritoneal and pericardial neoplasia that actually lacks valid therapies and in which cyclooxygenases-2 is recognized as an important adverse prognostic factor. Hence, there is an increasing interest in the development of new treatments based on cyclooxygenases-2 inhibitors, to prolong survival and even potentially cure this neoplasia.
Original language | English |
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Pages (from-to) | 1267-1274 |
Number of pages | 8 |
Journal | Histology and Histopathology |
Volume | 20 |
Issue number | 4 |
Publication status | Published - Oct 2005 |
Keywords
- Chemotherapy
- COX-2
- Mesothelioma
ASJC Scopus subject areas
- Anatomy
- Pathology and Forensic Medicine
- Histology
- Cell Biology