Cox and mesothelioma: An overview

I. Cardillo, E. P. Spugnini, A. Verdina, R. Galati, G. Citro, Alfonso Baldi

Research output: Contribution to journalArticlepeer-review

Abstract

Cyclooxygenases catalyze the rate limiting step in the production of prostanoids. Accumulating data demonstrate that overexpression of these enzymes, and in particular of cyclooxygenases-2, promotes multiple events involved in tumorigenesis; in addition, numerous studies show that inhibition of cyclooxygenases-2 can delay or prevent certain forms of cancer. Malignant mesothelioma is a lethal pleural, peritoneal and pericardial neoplasia that actually lacks valid therapies and in which cyclooxygenases-2 is recognized as an important adverse prognostic factor. Hence, there is an increasing interest in the development of new treatments based on cyclooxygenases-2 inhibitors, to prolong survival and even potentially cure this neoplasia.

Original languageEnglish
Pages (from-to)1267-1274
Number of pages8
JournalHistology and Histopathology
Volume20
Issue number4
Publication statusPublished - Oct 2005

Keywords

  • Chemotherapy
  • COX-2
  • Mesothelioma

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Histology
  • Cell Biology

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