Cox and mesothelioma: An overview

I. Cardillo, E. P. Spugnini, A. Verdina, R. Galati, G. Citro, Alfonso Baldi

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Cyclooxygenases catalyze the rate limiting step in the production of prostanoids. Accumulating data demonstrate that overexpression of these enzymes, and in particular of cyclooxygenases-2, promotes multiple events involved in tumorigenesis; in addition, numerous studies show that inhibition of cyclooxygenases-2 can delay or prevent certain forms of cancer. Malignant mesothelioma is a lethal pleural, peritoneal and pericardial neoplasia that actually lacks valid therapies and in which cyclooxygenases-2 is recognized as an important adverse prognostic factor. Hence, there is an increasing interest in the development of new treatments based on cyclooxygenases-2 inhibitors, to prolong survival and even potentially cure this neoplasia.

Original languageEnglish
Pages (from-to)1267-1274
Number of pages8
JournalHistology and Histopathology
Volume20
Issue number4
Publication statusPublished - Oct 2005

Fingerprint

Mesothelioma
Cyclooxygenase 2
Neoplasms
Cyclooxygenase 2 Inhibitors
Prostaglandin-Endoperoxide Synthases
Prostaglandins
Carcinogenesis
Enzymes
Therapeutics

Keywords

  • Chemotherapy
  • COX-2
  • Mesothelioma

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Histology
  • Cell Biology

Cite this

Cardillo, I., Spugnini, E. P., Verdina, A., Galati, R., Citro, G., & Baldi, A. (2005). Cox and mesothelioma: An overview. Histology and Histopathology, 20(4), 1267-1274.

Cox and mesothelioma : An overview. / Cardillo, I.; Spugnini, E. P.; Verdina, A.; Galati, R.; Citro, G.; Baldi, Alfonso.

In: Histology and Histopathology, Vol. 20, No. 4, 10.2005, p. 1267-1274.

Research output: Contribution to journalArticle

Cardillo, I, Spugnini, EP, Verdina, A, Galati, R, Citro, G & Baldi, A 2005, 'Cox and mesothelioma: An overview', Histology and Histopathology, vol. 20, no. 4, pp. 1267-1274.
Cardillo I, Spugnini EP, Verdina A, Galati R, Citro G, Baldi A. Cox and mesothelioma: An overview. Histology and Histopathology. 2005 Oct;20(4):1267-1274.
Cardillo, I. ; Spugnini, E. P. ; Verdina, A. ; Galati, R. ; Citro, G. ; Baldi, Alfonso. / Cox and mesothelioma : An overview. In: Histology and Histopathology. 2005 ; Vol. 20, No. 4. pp. 1267-1274.
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