Cox proportional hazard model to study ventricular tachycardia recurrences after surgery

C. Klersy, M. Comelli, R. De Ponti, M. Chimienti, M. Vigano, J. A. Salerno

Research output: Contribution to journalArticle

Abstract

The introduction of alternative methods (catheter ablation, ICD, cardiac transplant) to treat postinfarction (MI) drug resistant VT, has made it crucial in decision making to determine when surgery is still indicated. Aim of our study was to assess the predictive value of selected variables in terms of recurrences of VT, using Cox semiparametric proportional hazard model. The variable of interest was time between surgery and recurrence of VT ('free-interval analysis'). GLIM3 statistical package was used for computation. Between January 1980 and December 1988, 84 operated patients (79 males, 5 females, aged 55 ± 8 yrs) were included in the study. To avoid selection bias, later patients were not considered, due to the use of other treatments for patients with poor ejection fraction (EF). On a follow-up of 32 ± 25 months, 11 patients (13%) had recurrences of VT. Eleven selected covariates were tested. Marginal and conditional testing allowed to isolate only two independent prognostic factors for VT recurrences, i.e. ejection fraction and number of morphologies of VT. Risk increases for reduction of the ejection fraction and in patients with a single documented VT. In conclusion, on the basis of this model of risk, we suggest to consider other surgical treatments for patients with poor ventricular function and to carefully identify every morphology of VT to increase therapeutical efficacy.

Original languageEnglish
Pages (from-to)187-191
Number of pages5
JournalNew Trends in Arrhythmias
Volume8
Issue number1-2
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Klersy, C., Comelli, M., De Ponti, R., Chimienti, M., Vigano, M., & Salerno, J. A. (1992). Cox proportional hazard model to study ventricular tachycardia recurrences after surgery. New Trends in Arrhythmias, 8(1-2), 187-191.