COX1 and COX2 polymorphisms and gastric cancer risk in a polish population

Lifang Hou, Paolo Grillo, Zhong Zheng Zhu, Jola Lissowska, Meredith Yeager, Witold Zatonski, Guanshan Zhu, Andrea Baccarelli, Stephen J. Chanock, Joseph F. Fraumeni, Wong Ho Chow

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Background: Although a number of studies on the polymorphisms in COX1 and COX2 genes in association with risks for a number of cancers have been conducted, their relation to gastric cancer has not been well studied. Patients and Methods: Genotypes of several variants in both COX1 (Ex7+31 C>A and Ex10-4 G>A) and COX2 (-765 G>C, Ex10+837 T>C, Ex10-90 C>T, IVS5-275 T>G, and IVS7+111 T>C) were identified by TaqMan™ assays in 305 gastric cancer cases and 427 age- and gender-matched controls in a high-risk Polish population. Odds ratios for gastric cancer and 95% confidence intervals from unconditional logistic regression models were used to evaluate relative risks. Results: We found no statistically significant evidence that the polymorphisms tested in COX1 and COX2 are associated with gastric cancer risk. Conclusion: These results suggest that the polymorphisms examined in COX1 and COX2 do not affect the risk of gastric cancer.

Original languageEnglish
Pages (from-to)4243-4247
Number of pages5
JournalAnticancer Research
Volume27
Issue number6 C
Publication statusPublished - Nov 2007

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Industrial Oils
Stomach Neoplasms
Population
Logistic Models
Odds Ratio
Genotype
Confidence Intervals
Genes
Neoplasms

Keywords

  • COX1
  • COX2
  • Gastric cancer
  • Polymorphisms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Hou, L., Grillo, P., Zhu, Z. Z., Lissowska, J., Yeager, M., Zatonski, W., ... Chow, W. H. (2007). COX1 and COX2 polymorphisms and gastric cancer risk in a polish population. Anticancer Research, 27(6 C), 4243-4247.

COX1 and COX2 polymorphisms and gastric cancer risk in a polish population. / Hou, Lifang; Grillo, Paolo; Zhu, Zhong Zheng; Lissowska, Jola; Yeager, Meredith; Zatonski, Witold; Zhu, Guanshan; Baccarelli, Andrea; Chanock, Stephen J.; Fraumeni, Joseph F.; Chow, Wong Ho.

In: Anticancer Research, Vol. 27, No. 6 C, 11.2007, p. 4243-4247.

Research output: Contribution to journalArticle

Hou, L, Grillo, P, Zhu, ZZ, Lissowska, J, Yeager, M, Zatonski, W, Zhu, G, Baccarelli, A, Chanock, SJ, Fraumeni, JF & Chow, WH 2007, 'COX1 and COX2 polymorphisms and gastric cancer risk in a polish population', Anticancer Research, vol. 27, no. 6 C, pp. 4243-4247.
Hou L, Grillo P, Zhu ZZ, Lissowska J, Yeager M, Zatonski W et al. COX1 and COX2 polymorphisms and gastric cancer risk in a polish population. Anticancer Research. 2007 Nov;27(6 C):4243-4247.
Hou, Lifang ; Grillo, Paolo ; Zhu, Zhong Zheng ; Lissowska, Jola ; Yeager, Meredith ; Zatonski, Witold ; Zhu, Guanshan ; Baccarelli, Andrea ; Chanock, Stephen J. ; Fraumeni, Joseph F. ; Chow, Wong Ho. / COX1 and COX2 polymorphisms and gastric cancer risk in a polish population. In: Anticancer Research. 2007 ; Vol. 27, No. 6 C. pp. 4243-4247.
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AU - Zatonski, Witold

AU - Zhu, Guanshan

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