TY - JOUR
T1 - CP 55,940 protects against ischemia-induced electroencephalographic flattening and hyperlocomotionin Mongolian gerbils
AU - Braida, Daniela
AU - Pozzi, Morena
AU - Sala, Mariaelvina
PY - 2000/12/22
Y1 - 2000/12/22
N2 - The effect of CP 55,940, on electroencephalographic (EEG) spectral power decrease and hyperlocomotion induced by transient global ischemia in gerbils, was investigated. Animals were treated with CP 55,940 (4 mg/kg intraperitoneal (i.p.)) 5 min after bilateral carotid occlusion or SR 141716A (3 mg/kg i.p.) 5 min before or with both. Mean total and relative spectral power was evaluated for 1 h before (basal) and 1 and 24 h, 3 and 7 days after ischemia. Spontaneous locomotor activity was evaluated at the same times. CP 55,940 antagonized the reduction in mean total spectral power and the hyperlocomotion induced by ischemia, in comparison with vehicle group, starting from 24 h and lasting 7 days (P <0.001). Pretreatment with SR 141716A completely blocked the neuroprotective effect of CP 55,940. These findings suggest a potential therapeutic role of cannabinoids in cerebral ischemia. (C) 2000 Published by Elsevier Science Ireland Ltd.
AB - The effect of CP 55,940, on electroencephalographic (EEG) spectral power decrease and hyperlocomotion induced by transient global ischemia in gerbils, was investigated. Animals were treated with CP 55,940 (4 mg/kg intraperitoneal (i.p.)) 5 min after bilateral carotid occlusion or SR 141716A (3 mg/kg i.p.) 5 min before or with both. Mean total and relative spectral power was evaluated for 1 h before (basal) and 1 and 24 h, 3 and 7 days after ischemia. Spontaneous locomotor activity was evaluated at the same times. CP 55,940 antagonized the reduction in mean total spectral power and the hyperlocomotion induced by ischemia, in comparison with vehicle group, starting from 24 h and lasting 7 days (P <0.001). Pretreatment with SR 141716A completely blocked the neuroprotective effect of CP 55,940. These findings suggest a potential therapeutic role of cannabinoids in cerebral ischemia. (C) 2000 Published by Elsevier Science Ireland Ltd.
KW - Cannabinoid agonist
KW - CB1 receptor antagonist
KW - Electroencephalograph
KW - Gerbil
KW - Global ischemia
KW - Motor activity
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U2 - 10.1016/S0304-3940(00)01634-7
DO - 10.1016/S0304-3940(00)01634-7
M3 - Article
C2 - 11108983
AN - SCOPUS:0034704404
VL - 296
SP - 69
EP - 72
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 2-3
ER -