CP 55,940 protects against ischemia-induced electroencephalographic flattening and hyperlocomotionin Mongolian gerbils

Daniela Braida, Morena Pozzi, Mariaelvina Sala

Research output: Contribution to journalArticle

Abstract

The effect of CP 55,940, on electroencephalographic (EEG) spectral power decrease and hyperlocomotion induced by transient global ischemia in gerbils, was investigated. Animals were treated with CP 55,940 (4 mg/kg intraperitoneal (i.p.)) 5 min after bilateral carotid occlusion or SR 141716A (3 mg/kg i.p.) 5 min before or with both. Mean total and relative spectral power was evaluated for 1 h before (basal) and 1 and 24 h, 3 and 7 days after ischemia. Spontaneous locomotor activity was evaluated at the same times. CP 55,940 antagonized the reduction in mean total spectral power and the hyperlocomotion induced by ischemia, in comparison with vehicle group, starting from 24 h and lasting 7 days (P <0.001). Pretreatment with SR 141716A completely blocked the neuroprotective effect of CP 55,940. These findings suggest a potential therapeutic role of cannabinoids in cerebral ischemia. (C) 2000 Published by Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)69-72
Number of pages4
JournalNeuroscience Letters
Volume296
Issue number2-3
DOIs
Publication statusPublished - Dec 22 2000

Keywords

  • Cannabinoid agonist
  • CB1 receptor antagonist
  • Electroencephalograph
  • Gerbil
  • Global ischemia
  • Motor activity

ASJC Scopus subject areas

  • Neuroscience(all)

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