Abstract
Cranial neuralgias are paroxysmal painful disorders of the head characterised by some shared features such as unilaterality of symptoms, transience and recurrence of attacks, superficial and "shock-like" quality of pain and the presence of triggering factors. Although rare, these disorders must be promptly recognised as they harbour a relatively high risk for underlying compressive or inflammatory disease. Nevertheless, misdiagnosis is frequent. Trigeminal and glossopharyngeal neuralgias are sustained in most cases by a neurovascular conflict in the posterior fossa resulting in a hyperexcitability state of the trigeminal circuitry. If the aetiology of trigeminal neuralgia (TN) and other typical neuralgias must be brought back to the peripheral injury, their pathogenesis could involve central allodynic mechanisms, which, in patients with inter-critical pain, also engage the nociceptive neurons at the thalamic-cortical level. Currently available medical treatments for TN and other cranial neuralgias are reviewed.
| Original language | English |
|---|---|
| Journal | Neurological Sciences |
| Volume | 29 |
| Issue number | SUPPL. 1 |
| DOIs | |
| Publication status | Published - May 2008 |
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Keywords
- Cranial neuralgias
- Glossopharyngeal neuralgia
- Physiopathology
- Review
- Treatment
- Trigeminal neuralgia
ASJC Scopus subject areas
- Neuroscience(all)
- Clinical Neurology
Cite this
Cranial neuralgias : From physiopathology to pharmacological treatment. / Simone, Roberto; Ranieri, Angelo; Bilo, Leonilda; Fiorillo, Chiara; Bonavita, Vincenzo.
In: Neurological Sciences, Vol. 29, No. SUPPL. 1, 05.2008.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cranial neuralgias
T2 - From physiopathology to pharmacological treatment
AU - Simone, Roberto
AU - Ranieri, Angelo
AU - Bilo, Leonilda
AU - Fiorillo, Chiara
AU - Bonavita, Vincenzo
PY - 2008/5
Y1 - 2008/5
N2 - Cranial neuralgias are paroxysmal painful disorders of the head characterised by some shared features such as unilaterality of symptoms, transience and recurrence of attacks, superficial and "shock-like" quality of pain and the presence of triggering factors. Although rare, these disorders must be promptly recognised as they harbour a relatively high risk for underlying compressive or inflammatory disease. Nevertheless, misdiagnosis is frequent. Trigeminal and glossopharyngeal neuralgias are sustained in most cases by a neurovascular conflict in the posterior fossa resulting in a hyperexcitability state of the trigeminal circuitry. If the aetiology of trigeminal neuralgia (TN) and other typical neuralgias must be brought back to the peripheral injury, their pathogenesis could involve central allodynic mechanisms, which, in patients with inter-critical pain, also engage the nociceptive neurons at the thalamic-cortical level. Currently available medical treatments for TN and other cranial neuralgias are reviewed.
AB - Cranial neuralgias are paroxysmal painful disorders of the head characterised by some shared features such as unilaterality of symptoms, transience and recurrence of attacks, superficial and "shock-like" quality of pain and the presence of triggering factors. Although rare, these disorders must be promptly recognised as they harbour a relatively high risk for underlying compressive or inflammatory disease. Nevertheless, misdiagnosis is frequent. Trigeminal and glossopharyngeal neuralgias are sustained in most cases by a neurovascular conflict in the posterior fossa resulting in a hyperexcitability state of the trigeminal circuitry. If the aetiology of trigeminal neuralgia (TN) and other typical neuralgias must be brought back to the peripheral injury, their pathogenesis could involve central allodynic mechanisms, which, in patients with inter-critical pain, also engage the nociceptive neurons at the thalamic-cortical level. Currently available medical treatments for TN and other cranial neuralgias are reviewed.
KW - Cranial neuralgias
KW - Glossopharyngeal neuralgia
KW - Physiopathology
KW - Review
KW - Treatment
KW - Trigeminal neuralgia
UR - http://www.scopus.com/inward/record.url?scp=45249089446&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=45249089446&partnerID=8YFLogxK
U2 - 10.1007/s10072-008-0892-7
DO - 10.1007/s10072-008-0892-7
M3 - Article
VL - 29
JO - Neurological Sciences
JF - Neurological Sciences
SN - 1590-1874
IS - SUPPL. 1
ER -