Cranial repair: How complicated is filling a "hole"?

Pasquale De Bonis, Paolo Frassanito, Annunziato Mangiola, Carlotta Ginevra Nucci, Carmelo Anile, Angelo Pompucci

Research output: Contribution to journalArticlepeer-review


In general, cranioplasty is viewed as a straightforward surgical procedure, and for many years the complications associated with the procedure have been underestimated. We reviewed our 5-year experience consisting of 218 cranioplasties. Study outcomes focused specifically on the occurrence of complications after cranioplasty. Autologous bone-assisted and prosthetic cranioplasties were considered. Variables described by other authors to be associated with complications were studied, including history of previous cranioplasty, wider craniectomy size, bifrontal craniectomy, and delayed cranioplasty. We also analyzed the influence of material used for craniectomy on the occurrence of complications. The overall complication rate was 19.7%. Nineteen cases of infection (8.7%), 5 cases of postoperative wound dehiscence (2.3%), 6 cases of epidural hemorrhage (2.8%), and 13 cases of cranioplasty dislocation (5.9%) were observed. Bifrontal cranioplasties were more frequently associated with complications (p=0.01; Fisher's exact test) and infection (p

Original languageEnglish
Pages (from-to)1071-1076
Number of pages6
JournalJournal of Neurotrauma
Issue number6
Publication statusPublished - Apr 10 2012


  • autologous bone flap
  • cranial repair
  • cranioplasty
  • custom-made skull prosthesis
  • decompressive craniectomy

ASJC Scopus subject areas

  • Clinical Neurology


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