Creatinine excretion rate, a marker of muscle mass, is related to clinical outcome in patients with chronic systolic heart failure

Jozine M. Ter Maaten, Kevin Damman, Hans L. Hillege, Stephan J. Bakker, Stefan D. Anker, Gerjan Navis, Adriaan A. Voors

Research output: Contribution to journalArticlepeer-review

Abstract

Aims: In chronic heart failure (CHF), low body mass as a reflection of low muscle mass has been associated with poor outcome. Urinary creatinine excretion rate (CER) is an established marker of muscle mass, but has not been investigated in CHF. This study aims to evaluate urinary CER as a marker of muscle mass in patients with CHF and establish the relationship with clinical outcome.

Methods and results: In 120 patients with CHF, we evaluated CER as determined by mean creatinine excretion rate in two consecutive 24-h urine collections. We evaluated the relationship between CER and clinical variables using linear regression. Finally, we evaluated the association between CER and clinical outcome. Mean age was 59 ± 12 years, and 80 % were male. Mean CER was 1,383 mg/day (range 412–2,930). Independent predictors of CER were body surface area (BSA) (β = 0.404, P 

Conclusions: Low urinary CER is associated with smaller body dimensions and more severe heart failure and is associated with an increased risk of adverse outcome.

Original languageEnglish
Pages (from-to)976-983
Number of pages8
JournalClinical Research in Cardiology
Volume103
Issue number12
DOIs
Publication statusPublished - Nov 18 2014

Keywords

  • Creatinine excretion
  • Heart failure
  • Prognosis
  • Sarcopenia

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

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