Abstract
A highly crosslinked composite dextran-based scaffold (named DexFoam) was tailored to overcome specific deficiencies of polymeric and ceramic bone scaffolds and to guarantee a bone-mimicking microenvironment for the proliferation of human mesenchymal stem cells in vitro. The creep resistance for up to 90% compressive stain, the capability to regain the original shape after deformation, and the good thermal stability in both physiological and “body limit” conditions make DexFoam a valid alternative to the currently available bone scaffolds. Histopathological evaluation for host reaction and tissue colonization of DexFoam scaffold, implanted subcutaneously in mice, demonstrated its in vivo biocompatibility and biodegradability.
| Original language | English |
|---|---|
| Pages (from-to) | 729-740 |
| Number of pages | 12 |
| Journal | International Journal of Polymeric Materials |
| Volume | 65 |
| Issue number | 14 |
| DOIs | |
| Publication status | Published - Sep 21 2016 |
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Keywords
- Bone graft substitute
- composite scaffolds
- dextran
- polyurethane
- regenerative medicine
- tissue engineering
ASJC Scopus subject areas
- Polymers and Plastics
- Analytical Chemistry
- Chemical Engineering(all)
Cite this
Creep-resistant dextran-based polyurethane foam as a candidate scaffold for bone tissue engineering : Synthesis, chemico-physical characterization, and in vitro and in vivo biocompatibility. / Gerges, I.; Tamplenizza, M.; Lopa, S.; Recordati, C.; Martello, F.; Tocchio, A.; Ricotti, L.; Arrigoni, Chiara; Milani, P.; Moretti, M.; Lenardi, C.
In: International Journal of Polymeric Materials, Vol. 65, No. 14, 21.09.2016, p. 729-740.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Creep-resistant dextran-based polyurethane foam as a candidate scaffold for bone tissue engineering
T2 - Synthesis, chemico-physical characterization, and in vitro and in vivo biocompatibility
AU - Gerges, I.
AU - Tamplenizza, M.
AU - Lopa, S.
AU - Recordati, C.
AU - Martello, F.
AU - Tocchio, A.
AU - Ricotti, L.
AU - Arrigoni, Chiara
AU - Milani, P.
AU - Moretti, M.
AU - Lenardi, C.
PY - 2016/9/21
Y1 - 2016/9/21
N2 - A highly crosslinked composite dextran-based scaffold (named DexFoam) was tailored to overcome specific deficiencies of polymeric and ceramic bone scaffolds and to guarantee a bone-mimicking microenvironment for the proliferation of human mesenchymal stem cells in vitro. The creep resistance for up to 90% compressive stain, the capability to regain the original shape after deformation, and the good thermal stability in both physiological and “body limit” conditions make DexFoam a valid alternative to the currently available bone scaffolds. Histopathological evaluation for host reaction and tissue colonization of DexFoam scaffold, implanted subcutaneously in mice, demonstrated its in vivo biocompatibility and biodegradability.
AB - A highly crosslinked composite dextran-based scaffold (named DexFoam) was tailored to overcome specific deficiencies of polymeric and ceramic bone scaffolds and to guarantee a bone-mimicking microenvironment for the proliferation of human mesenchymal stem cells in vitro. The creep resistance for up to 90% compressive stain, the capability to regain the original shape after deformation, and the good thermal stability in both physiological and “body limit” conditions make DexFoam a valid alternative to the currently available bone scaffolds. Histopathological evaluation for host reaction and tissue colonization of DexFoam scaffold, implanted subcutaneously in mice, demonstrated its in vivo biocompatibility and biodegradability.
KW - Bone graft substitute
KW - composite scaffolds
KW - dextran
KW - polyurethane
KW - regenerative medicine
KW - tissue engineering
UR - http://www.scopus.com/inward/record.url?scp=84975252814&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84975252814&partnerID=8YFLogxK
U2 - 10.1080/00914037.2016.1163565
DO - 10.1080/00914037.2016.1163565
M3 - Article
AN - SCOPUS:84975252814
VL - 65
SP - 729
EP - 740
JO - International Journal of Polymeric Materials and Polymeric Biomaterials
JF - International Journal of Polymeric Materials and Polymeric Biomaterials
SN - 0091-4037
IS - 14
ER -