Creep-resistant dextran-based polyurethane foam as a candidate scaffold for bone tissue engineering: Synthesis, chemico-physical characterization, and in vitro and in vivo biocompatibility

I. Gerges; M. Tamplenizza; S. Lopa; C. Recordati; F. Martello; A. Tocchio; L. Ricotti; Chiara Arrigoni; P. Milani; M. Moretti; C. Lenardi

doi:10.1080/00914037.2016.1163565

Creep-resistant dextran-based polyurethane foam as a candidate scaffold for bone tissue engineering: Synthesis, chemico-physical characterization, and in vitro and in vivo biocompatibility

I. Gerges, M. Tamplenizza, S. Lopa, C. Recordati, F. Martello, A. Tocchio, L. Ricotti, Chiara Arrigoni, P. Milani, M. Moretti, C. Lenardi

IRCCS Istituto Ortopedico Galeazzi

Research output: Contribution to journal › Article › peer-review

Abstract

A highly crosslinked composite dextran-based scaffold (named DexFoam) was tailored to overcome specific deficiencies of polymeric and ceramic bone scaffolds and to guarantee a bone-mimicking microenvironment for the proliferation of human mesenchymal stem cells in vitro. The creep resistance for up to 90% compressive stain, the capability to regain the original shape after deformation, and the good thermal stability in both physiological and “body limit” conditions make DexFoam a valid alternative to the currently available bone scaffolds. Histopathological evaluation for host reaction and tissue colonization of DexFoam scaffold, implanted subcutaneously in mice, demonstrated its in vivo biocompatibility and biodegradability.

Original language	English
Pages (from-to)	729-740
Number of pages	12
Journal	International Journal of Polymeric Materials
Volume	65
Issue number	14
DOIs	https://doi.org/10.1080/00914037.2016.1163565
Publication status	Published - Sep 21 2016

Keywords

Bone graft substitute
composite scaffolds
dextran
polyurethane
regenerative medicine
tissue engineering

ASJC Scopus subject areas

Polymers and Plastics
Analytical Chemistry
Chemical Engineering(all)

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Gerges, I., Tamplenizza, M., Lopa, S., Recordati, C., Martello, F., Tocchio, A., Ricotti, L., Arrigoni, C., Milani, P., Moretti, M., & Lenardi, C. (2016). Creep-resistant dextran-based polyurethane foam as a candidate scaffold for bone tissue engineering: Synthesis, chemico-physical characterization, and in vitro and in vivo biocompatibility. International Journal of Polymeric Materials, 65(14), 729-740. https://doi.org/10.1080/00914037.2016.1163565

Creep-resistant dextran-based polyurethane foam as a candidate scaffold for bone tissue engineering : Synthesis, chemico-physical characterization, and in vitro and in vivo biocompatibility. / Gerges, I.; Tamplenizza, M.; Lopa, S.; Recordati, C.; Martello, F.; Tocchio, A.; Ricotti, L.; Arrigoni, Chiara; Milani, P.; Moretti, M.; Lenardi, C.

In: International Journal of Polymeric Materials, Vol. 65, No. 14, 21.09.2016, p. 729-740.

Research output: Contribution to journal › Article › peer-review

Gerges, I, Tamplenizza, M, Lopa, S, Recordati, C, Martello, F, Tocchio, A, Ricotti, L, Arrigoni, C, Milani, P, Moretti, M & Lenardi, C 2016, 'Creep-resistant dextran-based polyurethane foam as a candidate scaffold for bone tissue engineering: Synthesis, chemico-physical characterization, and in vitro and in vivo biocompatibility', International Journal of Polymeric Materials, vol. 65, no. 14, pp. 729-740. https://doi.org/10.1080/00914037.2016.1163565

Gerges I, Tamplenizza M, Lopa S, Recordati C, Martello F, Tocchio A et al. Creep-resistant dextran-based polyurethane foam as a candidate scaffold for bone tissue engineering: Synthesis, chemico-physical characterization, and in vitro and in vivo biocompatibility. International Journal of Polymeric Materials. 2016 Sep 21;65(14):729-740. https://doi.org/10.1080/00914037.2016.1163565

Gerges, I. ; Tamplenizza, M. ; Lopa, S. ; Recordati, C. ; Martello, F. ; Tocchio, A. ; Ricotti, L. ; Arrigoni, Chiara ; Milani, P. ; Moretti, M. ; Lenardi, C. / Creep-resistant dextran-based polyurethane foam as a candidate scaffold for bone tissue engineering : Synthesis, chemico-physical characterization, and in vitro and in vivo biocompatibility. In: International Journal of Polymeric Materials. 2016 ; Vol. 65, No. 14. pp. 729-740.

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