CREST biorepository for translational studies on malignant mesothelioma, lung cancer and other respiratory tract diseases: Informatics infrastructure and standardized annotation

Donatella Ugolini, Monica Neri, Luca Bennati, Pier Aldo Canessa, Georgia Casanova, Cecilia Lando, Giacomo Leoncini, Paola Marroni, Barbara Parodi, Claudio Simonassi, Stefano Bonassi

Research output: Contribution to journalArticle

Abstract

Advances in molecular epidemiology and translational research have led to the need for biospecimen collection. The Cancer of the Respiratory Tract (CREST) biorepository is concerned with pleural malignant mesothelioma (MM) and lung cancer (LC). The biorepository staff has collected demographic and epidemiological data directly from consenting subjects using a structured questionnaire, in agreement with The Public Population Project in Genomics (P 3G). Clinical and follow-up data were collected. Sample data were also recorded. The architecture is based on a database designed with Microsoft Access. Data standardization was carried out to conform with established conventions or procedures. As from January 31, 2011, the overall number of recruited subjects was 1,857 (454 LC, 245 MM, 130 other cancers and 1,028 controls). Due to its infrastructure, CREST was able to join international projects, sharing samples and/or data with other research groups in the field. The data management system allows CREST to be involved, through a minimum data set, in the national project for the construction of the Italian network of Oncologic BioBanks (RIBBO), and in the infrastructure of a pan-European biobank network (BBMRI). The CREST biorepository is a valuable tool for translational studies on respiratory tract diseases, because of its simple and efficient infrastructure.

Original languageEnglish
Pages (from-to)540-546
Number of pages7
JournalExperimental and Therapeutic Medicine
Volume3
Issue number3
DOIs
Publication statusPublished - Mar 2012

Keywords

  • Italy
  • Lung neoplasms
  • Mesothelioma
  • Molecular epidemiology
  • Specimen handling
  • Translational research

ASJC Scopus subject areas

  • Medicine(all)
  • Cancer Research
  • Immunology and Microbiology (miscellaneous)

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