Creutzfeldt-Jakob disease after liver transplantation

Alain Créange, Françoise Gray, Pierre Cesaro, Homa Adle-Biassette, Christophe Duvoux, Daniel Cherqui, Jeanne Bell, Piero Parchi, Pierluigi Gambetti, Jean Denis Degos

Research output: Contribution to journalArticlepeer-review

Abstract

We report a 57-year-old woman who died from Creutzfeldt-Jakob disease 2 years after a liver transplantation. The liver donor had no history of neurological disease. In one albumin donor, possible Creutzfeldt-Jakob disease developed 3 years later. The patient initially had cerebellar symptoms. Neuropathology included 'Kuru-type' plaques and prion protein (PrP) deposits involving the cerebellum predominantly. The patient was homozygote valine at codon 129 of the PrP gene while the liver was homozygote methionine. This observation raises the possibility of transmission of Creutzfeldt-Jakob disease by the graft itself or the associated albumin transfusions and, on a wider extent, by nonneural tissue.

Original languageEnglish
Pages (from-to)269-272
Number of pages4
JournalAnnals of Neurology
Volume38
Issue number2
DOIs
Publication statusPublished - Aug 1995

ASJC Scopus subject areas

  • Neuroscience(all)

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